G: Neutrophil - P notes

Question 1

Neutrophils - name due to nucleus?

Answer 1

. Polymorphonuclear cells

Question 2

Abundance of neutrophils in the blood

Answer 2

Most abundant leukocyte in the blood

Question 3

What happens to the number of neutrophils during acute bacterial infection

Answer 3

Raised number of neutrophils in acute bacterial infection

Question 4

Recall key features of neutrophils

Answer 4

. Polymorphonuclear cells
. Phagocytic - filled with granules, lysosomes which fuse with ingested phagosome to digest the pathogen
. Sensitive to chemotactic factors - attraction to infection site

Question 5

What do neutrophils form ?

Answer 5

Neutrophils form PUS

Question 6

PUS - elaborate

Answer 6

. Thick white-yellow fluid which results from the accumulation of
. WBCs
. Liquified tissue
. Cellular debris

Question 7

Factors affecting neutrophil abundance and turnover - how to measure neutrophil turnover in vivo

Answer 7

. Radioactive species that bind to DNA
. Measure counts over a period of time to determine turnover

Question 8

Neutrophils - adherence to vessel walls

Answer 8

• Integrins = expressed by neutrophils bind to ICAM
• ICAM = intracellular cell adhesion molecule
• Invasion of neutrophils into tissues in between 2 endothelial cells