Cytology Flashcards
List cytologic characteristics of epithelial tumors (shared)
Intercellular junctions, exfoliate well, sheets or clusters
What is the most common malignancy of the epidermis?
SCC
What are some cytologic features suggestive of a squamous cell carcinoma?
Keratinization (individualization of cells, sharp angular cytoplasmic margins), turquoise cytoplasm, magenta cytoplasmic inclusions (keratohyaline granules)
Cytologic features of salivary gland tumors
3D clusters, few to many secretory vacuoles
What is a signet ring cell and what neoplasias may it be present in?
Single large vacuole displacing nucleus eccentrically
Salivary gland tumors, mammary tumors
Describe cytologic features of a perianal gland tumor
Cohesive clusters resembling hepatocytes with distinct margins
What are some cytologic features which may help you identify a hepatocellular carcinoma?
Disorganized and forming 3D clusters, cytologic features of atypia
What are some cytologic features supporting an exocrine pancreatic origin?
Numerous small eosinophilic globules in basophilic cytoplasm, cuboidal cells
Which tumor type are renal carcinomas mistaken for on cytology?
Neuroendocrine tumors
Which cell type in addition to small, mature lymphocytes is present in canine thymomas?
Mast cells
What do anaplastic carcinomas of the GIT resemble cytologically?
Discrete round cell tumors
Describe the cytologic appearance of goblet cells
Large pale blue cytoplasmic inclusion, present sometimes in FNA of polyps
What is the cytologic appearance of endocrine/neuroendocrine tumors?
highly cellular, loosely cohesive sheets and clusters of epithelial cells with ill-defined intercellular junctions and cytoplasmic margins, numerous free nuclei
What is a cytologic feature unique to thyroid tumors?
General features of endocrine tissues + blue-black cytoplasmic granules
Which additional stain can help identify a pheochromocytoma?
Silver stains
