(15) Pharmacological Manipulation of Female Reproduction

Question 1

(Pharmacological Manipulation of Female Reproduction)

JUST READ THE FIRST PAGE

Question 2

(mimic the CL by administering progestagens)

(cattle)

(melengesterol acetate (MGA))

1. given how?
2. given to feedlot heifers to do what?
3. what is bad about this?

so do what?

Answer 2

1. orally
2. prevent pregnancy
3. fertitlity at first cycle isn’t so good

wait through first - lyse CL - fertilize on second

Question 3

Mimic the CL by administering progestagens

(cattle)

(CIDR-B - controlled internal drug release (T shaped))

1. intravaginal
2. leave in for how long? why no longer?
3. give PGE injection on day 6 - why?
4. estrus expected how soon after removal?

Answer 3

2. 7 days; longer gives reduced conception
3. lyse the CL
4. 1-3 days after removal (breed 12 hours after detection)

(PRID - progesterone-releasing intravaginal device (coil) is similar)

Question 4

Mimic the CL by administering progestagens

(cattle)

(Synchro-Mate B)

1. what is it?
2. estradiol is supposed to be what?
3. most in heat how soon after removal?
4. works better if you give what on day of removal?

Answer 4

1. ear implant (norgestomet) + injection (estradiol valerate + norgestomet)
2. luteolytic
3. 4 days
4. PGF2a

Question 5

Mimic the CL by administering progestagens

(Sheep and Goats)

1. what’s only thing available in US?
2. what used to be used?
3. in other parts of the world used what?

can give vaginitis… so do what?

4. what are becoming more common now (also in US)?
5. usually give for 8-14 days with what at the end?

Answer 5

1. MGA
2. syncro-mate
3. prosestagen impregnated sponges

coat with tetracycline powder

4. CIDR
5. PGE dose

Question 6

Mimic the CL by administering progestagens

(Horses)

1. what is used in horses?
2. how given?
3. give for 8-12 days with what on last day?

most mares show estrus how many days after shot?

4. always make sure of what before using?

Answer 6

1. Regumate
2. in feed
3. PGF injection

2-5

4. the mare doesn’t have a uteine infection

(progesterone bad for uterine defense)

Question 7

Mimic the CL by administering progestagens

(Bitches)

1. induction of what is always a risk?

(Megestrol Acetate (Ovaban))

2. no loger in US
3. given orally….
4. in proestrus to do what?

what style?

may fail if what?

5. in anestrus to do what?

what style

start when?

Answer 7

1. pyometra
2. stop entering heat

high dose short time

start to early –> cycles when stop

start too late –> cycles despite Rx

5. to delay next heat

low dose long time

1-2 weeks before next expected proestrus

Question 8

(Lyse the CL)

1. for this to work must have what two things?
2. what are the two popular ones?
3. Can use 1 dose but only what percentage works?

why?

so do what?

Answer 8

1. 1. animals have to be cycling
2. 2 CL has to be at respnsive stage of development
3. lutalyse (dinoprost)

estrumate (cloprostenol)

3. 60%

need to have susceptible CL

give two injections

( second timed so that animals not responding to the first will respond to the second and those that did respond to the first will also have a suitable CL to respond again.)

Question 9

(Lyse the CL)

(Cattle)