Lecture 18

Question 1

What are the effector cells in the antibody-mediated immune response to viruses?

Answer 1

• antibody
• complement activated by IgG or IgM

Question 2

What is the activity associated with the antibody-mediated immune response to viruses?

Answer 2

• Blocks: binding of virus to host cell, fusion of viral envelope with host cell membrane.
• Enhances phagocytosis (opsonization)
• Agglutinates viral particles
• Mediates opsonization and lysis

Question 3

What are the effector molecules in the cell-mediated immune response to viruses?

Answer 3

• INF-y secreted by Th or CTL cells
• NK cells and macrophages

Question 4

What is the activity associated with the cell-mediated immune response to viruses?

Answer 4

-Has direct antiviral activity
-Kills virus infected cells by antibody-dependent cell-mediated cytotoxicity (ADCC)

Question 5

List the structural components of a virus.

Answer 5

• DNA or RNA genes
• Capsid
• Capsomeres
• Envelope
• Proteins

Question 6

What are the steps in a virus infection?

Answer 6

1. Adsorption
2. Endocytosis of the virion, or fusion to the plasma membrane.
3. Capsid is dismantled, the nucleic acid is released into the cytoplasm (uncoating).
4. Replication begins

Question 7

Describe the process of DNA virus replication.

Answer 7

1. Infectious viral DNA replication
2. New viral DNA undergoes transcription
3. Viral RNA undergoes translation
4. Viral protein
5. Virus assembly

Question 8

Describe the process of RNA virus replication.

Answer 8

1. • strand
2. Infectious viral RNA undergoes replication.
3. New viral RNA undergoes translation.
4. Viral protein
5. Virus assembly

Question 9

Describe the process of Retrovirus (lentivirus) replication.

Answer 9

1. Infectious viral RNA ( - strand) undergoes reverse transcription
2. Viral DNA undergoes transcription
3. Viral RNA undergoes translation
4. Viral protien
5. Virus assembly

Question 10

Which of these are included in the innate viral immune response?
A. Cytotoxic T cells
B. NK cells
C. Type I interferons
D. B&C

Answer 10

B&C - the innate immune response to viral infections include the induction of Type I interferons and activation of NK cells

Question 11

T/F: The adaptive immune response to viruses include the generation of just cytotoxic T cells.

Answer 11

False - this response includes the generation of cytotoxic T cells AND neutralizing antibodies.

Question 12

In the earliest immune response of the host to a viral infection, what is produced?

Answer 12

Type I interferons alpha and beta