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General study MD3 > Medication GP > Flashcards

Medication GP Flashcards

1
Q

DPP4 inhibitors - MOA, agents, side effects

A

MOA: DPP4 inhibitor - increases endogenous incretin effect by inhibiting DPP4 that breaks down GLP-1, causing increased insulin secretion, decreased glucagon secretion, delayed gastric emptying. Used to treat T2DM
Agents: Linagliptin (trajgenta), sitagliptin, saxagliptin, alogliptin
Side effects: Diarrhoea, constipation, urinary infections, worsening renal function, increased satiety

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2
Q

SNRI - Class, MOA, agents, indications, side effects

A

Class: antidepressant
MOA: Inhibit serotonin and noradrenaline reuptake
in synaptic cleft, increasing serotonin and noradrenaline levels
Agents: duloxetine, venlafaxine, milnacipran
Indications: MDD, GAD, neuropathic pain, (with milnacipran) fibromyalgia, stress incontinence in women
Side effects: Insomnia, strange dreams, nightmares, increased BP, GI upset, SIADH, sexual dysfunction, increased cholesterol and triglycerides

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3
Q

SSRI - Class, MOA, agents, indications, side effects

A

Class: Antidepressant
MOA: Inhibit the presynaptic reuptake of serotonin (5-hydroxytryptamine, 5HT), increasing serotonin levels
Agents: Fluoxetine, paroxetine, sertraline, citalopram, escitalopram, fluvoxamine
Indications: MDD, GAD, OCD, PTSD, panic disorder, premature ejaculation, binge eating disorder, bulimia nervosa, SAD, gambling disorder
Side effects: Headache, N+V, diarrhea, agitation, anxiety (these should resolve within 1 week). Sexual dysfunction; serotonin syndrome - tremor, nausea; SIADH.

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4
Q

Meloxicam (mobic, moxicam, melobic)

A

Selective COX-2 inhibitor NSAID

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5
Q

NSAIDS - MOA, agents, side effects, contraindications

A

MOA: Analgesic, antipyretic and anti-inflammatory actions. Inhibit synthesis of prostaglandins by inhibiting cyclo-oxygenase (COX) present as COX1 and COX2
- Inhibition of COX1 results in impaired gastric cytoprotection and antiplatelet effect
- inhibition of COX2 results in anti-inflammatory and analgesic action
- Reduction in GFR and renal blood flow occurs with both COX1 and COX2 inhibition
Most NSAIDs are nonselective, inhibiting both COX1 and COX2. Reversible inhibition of COX1 and COX 2 causes decreased prostaglandin synthesis. Aspirin irreversible.
Agents: Ibuprofen, diclofenac, indomethacin, naproxen, meloxicam, piroxicam, ketorolac, aspirin
Side effects: Gastric and duodenal ulcers, increased risk of heart attack and stroke (not with aspirin and naproxen), renal function impairment (prostaglandins maintain renal blood flow by vasodilating afferent arterioles)
Contraindications: Acute haemmorhage, gastroduodenal ulcers, renal failure, pregnancy, pre-surgery (cease 1-3 days prior)

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6
Q

Selective COX-2 inhibitor NSAIDs - MOA, agents, indications, side effects, contraindications

A

MOA: selectively inhibit COX-2 enzyme with no or minimal inhibition of COX-1. (COX-2 found in cells that mediate pain and inflammation - macrophages, leukocytes; and vascular endothelial cells)
Analgesic and anti-inflammatory, advantageous over non-selective due to no anti-platelet effect, minimal gastric side effects and reduced risk of gastric ulcers
Agents: Celecoxib
Indications: RA, OA, acute pain, patients with history of peptic ulcer disease and platelet disorders
Side effects: increased risk of thrombosis, MI, stroke; sulfa drug reaction
Contraindications: Severe HF, recent MI or GI bleed, sulfa drug allergy

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7
Q

Indometacin

A

nonselective NSAID

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8
Q

Diclofenac

A

Nonselective NSAID

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9
Q

Xanthine oxidase inhibitors - MOA, agents, indication, side effects

A

MOA: Inhibit xanthine oxidase which reduces production of uric acid, lowering serum urate concentration and allowing acute flares and crystal deposits to resolve if long-term serum urate <0.36mmol/L
Agents: Allopurinol (preferred first line treatment), febuxostat
Indication: Urate-lowering therapy, gout
Side effects: Rash, stevens-Johnson syndrome/toxic epidermal necrolysis

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10
Q

Allopurinol: class + indications

A

Xanthine oxidase inhibitor
Indications: symtomatic hyperuricemia (gout)

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11
Q

Febuxostat (class + indications)

A

Xanthine oxidase inhibitor
Indications: symtomatic hyperuricemia (gout) - second line behind allopurinol

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12
Q

Cefalexin (cephalex, ibilex, keflex, cephalexin) - class and indications

A

Cephalosporin
Staphylococcal and streptococcal infections in people with mild to moderate penicillin allergy, UTI, epididymo-orchitis (urinary tract source)

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13
Q

Cefazolin - class

A

Cephalosporin (Abx)

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14
Q

Cefaclor - class

A

Cephalosporin (Abx)

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15
Q

Cephalosporins - MOA, agents, coverage, indications, side effects

A

MOA: Broad-spectrum. Interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death; bactericidal.
Agents:
1st generation: Cephalexin (oral), cefazolin (IV, IM)
2nd generation: Cefaclor, cefuroxime (oral)
Coverage: Highly active against gram +ve bacteria, 1st - 3rd gen most to least active. Active against some gram -ve bacteria (proteus mirabalis, e coli, klebsiella pneumoniae, no atypical coverage (chlamydia, mycoplasma, legionella). Indications: Cefazolin for perioperative wound infection prophylaxis (covers s. aureus). Ceftriaxone specifically has good CNS penetrance - meningitis, also used for gonnorhea and lyme disease
Side effects: Vitamin K deficiency, autoimmune hemolytic anemia

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16
Q

Carbapenems - MOA, agents, coverage, indications, side effects

A

MOA: Inhibit bacterial cell wall synthesis by binding to penicillin-binding proteins, the affinities for which differ between the carbapenems and may affect their activity in vitro; usually bactericidal.
Agents: Imipenem, meropenem, ertapenem, doripenem (all IV)
Coverage: Broad spectrum w intrinsic beta lactamase resistance; gram positive cocci (except for MRSA, enterococcus fecalis and enterococcus faecium) gram -ve rods, anaerobes
Indications: Last resort drugs (used in life threatening infections or after other antibiotics due to significant adverse effects)
Side effects: Secondary fungal infections, CNS toxicity - can lower seizure threshold at high serum concentrations, GI upset, rash, thrombophlebitis

17
Q

Macrolides - MOA, agents, coverage, indications, side effects, special considerations, contraindications

A

MOA: Bacteriostatic; inhibit bacterial protein synthesis by binding to the 23S ribosomal RNA molecule of the 50S ribosomal subunit leading to inhibition of bacterial protein synthesis. They also have immunomodulatory and anti-inflammatory effects.
Agents: Erythromycin, azithromycin, clarithromycin (oral or IV), roxithromycin (oral).
Coverage: Atypical pneumonia caused by mycoplasma pneumonia, legionella pneumonia, chlamydophilia pneumoniae; bordetella pertussis, chlamydia, gram +ve cocci (esp streptococcal infection in pts allergic to penicillin), neisseria (dual therapy with ceftrizxone for N. gonorrhea - azithromycin, mycobacterium avium, h pylori
Side effects: GI upset (increased intestinal motility), QT interval prolongation (arrhythmia), eosinophillia, rash, increased risk of hypertrophic pyloric stenosis (erythromycin and azithromycin) in infants up to 6 weeks of age
Special considerations:
Poor CNS penetration, biliary elimination, short half life
CI’s: Pregnancy (erythromycin and clarithromycin (teratogenic), hepatic failure, children <12, renal failure

18
Q

Azithromycin

A

Macrolide

19
Q

Clarithromycin

A

Macrolide

20
Q

Erythromycin

A

Macrolide

21
Q

Natural penicillin - MOA, agents, coverage, indications, side effects

A

MOA: Bactericidal; interfere with bacterial cell wall peptidoglycan synthesis by binding to penicillin-binding proteins, eventually leading to cell lysis and death.
Agents: Natural: Penicillin G (benzylpenicillin) - IV (crystalline penicillin G), IM (procaine penicillin G, benzathine penicillin G)
; penicillin V (phenoxymethylpenicillin) - oral.
Coverage: Gram +ve aerobes (esp streptococcus pyogenes, strep pneumoniae). Gram -ve cocci (esp neisseria meningitidis). Spirochetes (esp. treponema pallidum). Branching gram +ve anaerobes (esp actinomyces)
Side effects: Hypersensitivity reactions, hemolytic anemia positive direct coombs test, drug induced interstitial nephritis, seizures

22
Q

Amoxicillin - class and indications

A

Penicillin

Indications - exacerbation of chronic bronchitis, CAP, acute otitis media, sinusitis, gonococcal infection, epididymo-orchitis, acute prostatitis, acute pyelonephritis, UTI, endocarditis prophylaxis in high risk patients, acute cholecystitis, peritonitis, eradication of H pylori

23
Q

Amoxicillin with clavulanic acid (amoxiclav) MOA

A

Clavulanic acid inhibits beta-lactamase, which extends spectrum of activity of amoxicillin with clavulanic acid to cover some beta-lactamase-producing organisms.

24
Q

Amoxiclav indications

A

HAO, epididymo-orchitis (urinary tract source), PID (not sexually acquired), UTI, bites and clenched fist injuries, acute otitis media, sinusitis (unresponsive to amoxicillin), acute cholecystitis, melioidosis

25
Q

Ampicillin - class

A

Penicillin

26
Q

What is lexapro?

A

Escilatopram - SSRI

27
Q

What is targin?

A

Oxycodone with naloxone - opioid analgesic

28
Q

Oxycodone class, indications

A

Opioid analgesic
Severe pain

29
Q

Naloxone - class, MOA, indication

A

Class: Opioid receptor antagonist
MOA: High binding affinity to the mu opioid receptor
Indication: used to reverse opioid overdose. Short duration of action

30
Q

Penicillinase-resistant penicillins: Special characteristics, agents, coverage, side effects,

A

Special characteristics: B-lactamase resistant through addition of bulkt side chains which prevent bacterial beta lactamase from hydrolyzing the beta lactam ring
Agents: Nafcillin, dicloxacillin, oxacillin, floxacillin, methicillin
Coverage: Narrow spectrum; gram +ve aerobes (esp. staph aureus (non MRSA)). Not effective against streptococcus viridans, enterococci or listeria
Side effects: Interstitial nephritis, hypersensitivity reactions

31
Q

Aminopenicillins (penicillinase-sensitive penicillins) - agents, coverage, side effects

A

Susceptible to degradation by beta lactamase
Agents: Amoxicillin (oral or VI) - can be combined with clavulanate; ampicillin (IV or IM) (with or without sulbactam)
Coverage: Gram +ve aerobes,
Gram -ve rods (not effective against enterobacter spp). Most effective against; h pylori, h influenzae, e coli, listeria monocytogenes, proteus miribalis, salmonella, shigella, enterococcu, spirochetes
Side effects: diarrhea, pseudomembranous colitis, hypersensitivity reactions, drug induced rash.

Aminopeniciilin therapy HHEELPSSS.

32
Q

Midazolam - class

A

Class: Short acting, sedative-hypnotic benzodiazepine with anxiolytic and amenstic properties

33
Q

Benzodiazepines - MOA, agents, indications, side effects, special considerations

A

MOA: Indirect GABAa receptor agonists that bind to GABA-A receptors, increasing affinity of GABA to bind to GABAa receptors, increasing opening of chloride channels, leading to hyperpolarization of postsynaptic neuronal membrane, decreased neuronal excitability. Decrease duration of N3 phase NREM sleep. Effects; anxiolysis, sedation, hypnotic action, muscle relaxation, anticonvulsant, amnesia
Agents: Short acting (half-life 1-12 hrs); midazolam, triazolam, intermediate (half life 12-40 hrs); lorazepam, temazepam, oxazepam; long acting (half life >40hrs); diazepam, clonazepam, tetrazepam, flurazepam, chloridiazepoxide
Indications: Anxiety disorders, insomnia, alcohol withdrawal, seizures and status elipticus, preoperative and procedural sedation.
Side effects: anterograde amnesia, confusion, blunted affect, residual sedation, paradoxical reactions (incl restlessness, irritability)
Special considerations: all metabolised by the liver, but Lorazepam, oxazepam and temazepam undergo biotransformation through glucoronidation, not CYP450 activation and are less affected by liver disease

34
Q

Four classes of anti-arrhythmic drugs with examples and uses

A

Class 1: Fast sodium channel blockers (negative dromotropy). Class 1a: E.g Quinidine, procainamide, disopyramide, ajmaline. Use: PSVT, ectopic SVT, atrial fibrillation and atrial flutter, ventricular arrhythmias. Class1b: lidocaine, phenytoin, mexiletine
Class1c: Flecanide, propafenone.

Class 2: Beta blockers; inhibit beta-adrenergic activation of adenylate cyclase, causes decreased cAMP, decreased Ca2+, decreased SA and AV node activity. Prolong AV node repolarization (prolongation of PR interval). Slow conduction velocity. E.g. Metroprolol, esmolol, propanolol, atenolol, timolol, carvedilol, sotalol. Use: atrial fibrillation, atrial flutter, PSVT. Side effects: AV block, bradycardia, heart failure, exacerbation of asthma/COPD, sedation, CNS depression

Class 3: Potassium channel blockers; inhibit delayed rectifier potassium currents, prolong QT interval, no effect on conduction velocity. E.g Amiodarone, sotalol, bretylium, ibutilide, dofetilide. Uses: ventricular tachycardia (amiodarone and sotalol, AF, Aflutter

Class 4: Calcium channel blockers; inhibit slow calcium channels, prolong AV node repolarization, prolong PR interval. E.g verapamil, diltiazem, nifedipine

General study MD3 (8 decks)

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