Mod. 1 Chapter 10 Review Questions And Ppt

Question 1

The megakaryocyte progenitor that undergoes endomitosis is:
A. BFU-Meg
B. MK-1
C. LD-CFU-Meg
D. CFU-Meg

Answer 1

C. LD-CFU-Meg

Question 2

The growth factor that is produced in the kidney and induces growth and differentiation of commited megakaryocyte progenitor is:
A. IL-3
B. IL-6
C. IL-11
D. Thrombopoietin

Answer 2

D. Thrombopoietin

Question 3

What platelet organelle sequesters ionic calcium and binds a series of enzymes of the eicosanoid pathway?
A. Dense granules
B. Dense tubular system
C. Surface connected cannicular system
D. Glycocalyx

Answer 3

B. Dense tubular system

Question 4

White clots are:
A. Largely composed of platelets and VWF
B. Occur primarily in the deep veins of the legs
C. Characteristic of the secondary hemostatic process
D. Form normally in response to vascular injury and are completely harmless

Answer 4

A. Largely composed of platelets and VWF

Question 5

What platelet membrane receptor binds fibrinogen and supports platelets aggregation?
A. GP Ib/IX/V
B. GP Ia/IIa
C. GP IIb/IIIa
D. P2Y1

Answer 5

C. GP IIb/IIIa

Question 6

What platelet membrane phospholipid flips from the inner surface to the plasma surface on activation and serves as the assembly point of coagulation factors?
A. Phosphatidylethanolamine
B. Phosphatidylinositol
C. Phosphatidylserine
D. Phosphatidylcholine

Answer 6

C. Phosphatidylserine

Question 7

Reticulated platelets can be enumerated in peripheral blood to detect:
A. Impaired platelet production in disease states
B. Abnormal organelles associated with diseases such as leukemia
C. Increased platelet production in response to need
D. Inadequate rates of membrane cholesterol exchange with the plasma

Answer 7

C. Increased platelet production in response to need

Question 8

What plasma protein is essential for platelet adhesion?
A. Von willebrand factor
B. Factor VIII
C. Fibrinogen
D. P-selectin

Answer 8

A. Von willebrand factor

Question 9

Which of the following molecules is stored in platelet dense granules?
A. Fibrinogen
B. Serotonin
C. Platelet factor 4
D. Platelet derived growth factor

Answer 9

B. Serotonin

Question 10

What is the name of the eicosanoid metabolite produced from endothelial cells that suppresses platelet activity?
A. Thromboxane A2
B. Arachidonic acid
C. Cyclooxygenase
D. Prostacyclin

Answer 10

D. Prostacyclin

Question 11

Microparticles:
A. Are stored in platelet dense granules
B. Inhibit blood clotting
C. Bud off of platelets after their exposure to strong agonist
D. Exhibit no biologic activity

Answer 11

C. Bud off of platelets after their exposure to strong agonist

Question 12

Upon activation, platelets secrete their a-granule contents via:
A. The dense tubular system
B. The surface connected cannicular system
C. The glycocalyx
D. Microtubules

Answer 12

B. The surface connected cannicular system

Question 13

Enumerate the 3 types of blood vessels

Answer 13

• arteries and veins
• arterioles and venules
• capillaries

Question 14

______ is a reflex in which blood vessels narrow to increase blood pressure

Answer 14

Vasoconstriction

Question 15

_____ and _____ promotes vasoconstriction

Answer 15

Epinephrine and serotonin

Question 16

_______ causes vasoconstriction

Answer 16

Thromboxane A2

Question 17

_____ ensures rapid lysis of fibrin clots

Answer 17

Plasminogen

Question 18

______ Acts as modulators of vasomotor tone, cell proliferation, and hormone production

Answer 18

Endothelins

Question 19

Which of the 3 members of the endothelin family is produced in endothelial cells and is also produced in vascular smooth muscle cells?

Answer 19

Endothelin 1

Question 20

Which of the 3 members of the endothelin family is produced predominantly in kidney and intestine, with smaller amounts produced in the myocardium, placenta and uterus

Answer 20

Endothelin 2

Question 21

Which of the 3 members of the endothelin family has been found in high concentration in the brain and is also found throughout the gastrointestinal tract and in the lung and kidney?

Answer 21

Endothelin 3

Question 22

____ play an important role in the initiation, progression, and clinical complications of various forms of inflammatory and degenerative vascular diseases

Answer 22

Endothelial dysfunction

Question 23

_______ is the hormone thought to stimulate the production and maturation of megakaryocytes

Answer 23

Thrombopoietin

Question 24

Megakaryoblast
Size:______
Nucleus:_______
N/C ratio:_____

Answer 24

10-24mm
Round
3:1

Question 25

Promegakaryocyte
Size:______
Nucleus:_____
N/C ratio: ______

Answer 25

15-40mm
Indented
1:2

Question 26

Megakaryocyte
Size: _____
Nucleus:_____
N/C ratio:_____

Answer 26

Up to 160mm
Multilobe
1:4

Question 27

______ surrounds the cellular membrane of the platelet externally

Answer 27

Glycocalyx / fluffy coat

Question 28

An average megakaryocyte produces about ____ to ____ platelets

Answer 28

1000 to 2000

Question 29

Maturation period of megakaryocyte is

Answer 29

5 days

Question 30

Platelets initially enter the spleen and remains for how many days?

Answer 30

2

Question 31

The life span of a mature platelet is

Answer 31

9.0 days ± 1day

Question 32

A normal person has an average of ______ platelets in the systemic circulation

Answer 32

250 x 10^9/L

(pero nag rerange siya 150 to 450 x 10^9/L)