Endocrinology

Question 1

Which of the following is the most common cause of Cushing’s syndrome?
a. Ectopic ACTH production by tumors
b. Adrenal hyperplasia
c. Pituitary adenoma
d. Overuse of corticosteroids

Answer 1

d. Overuse of corticosteroids

Question 2

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) causes which of the following?
a. Low serum electrolytes
b. Urine osmolality to be lower than plasma
c. Low serum vasopressin
d. Hypernatremia

Answer 2

a. Low serum electrolytes

Question 3

Which of the following is the major mineralocorticoid?
a. Corticosterone
b. Cortisol
c. Aldosterone
d. Norepinephrine

Answer 3

c. Aldosterone

Question 4

Hyperparathyroidism is most consistently associated with which of the following?
a. Metabolic alkalosis
b. Hypocalcemia
c. Hypophosphatemia
d. Hypercalciuria

Answer 4

c. Hypophosphatemia

Question 5

A 35-year-old man presented with insidious onset of paresthesia, headache and weakness. PE reveals hypertension, an enlarged tongue and coarse facial
features. Which of the following is consistent with the most likely diagnosis?
a. An elevated IGF-1 level
b. Postprandial glucose of 70 mg/dl
c. Fasting glucose level of 95 mg/dL
d. GH suppression to 0.2 ug/L after 100-gm OGTT

Answer 5

b. Postprandial glucose of 70 mg/dl

Question 6

A serum thyroid panel reveals an increase in total T4, normal TSH, and a normal fT4. What is the most likely cause of these results?
a. Subclinical hypothyroidism
b. Increased thyroxine-binding protein
c. Secondary hyperthyroidism
d. Subclinical hyperthyroidism

Answer 6

c. Secondary hyperthyroidism

Question 7

Which of the following thyroid panel results is seen in patients with suspected myxedema?
a. Increased FT4, increased thyroid hormone
binding ratio, decreased TSH
b. Increased FT4, decreased thyroid hormone binding ratio, increased TSH
c. Decreased FT4, decreased thyroid hormone binding ratio, increased TSH
d. Decreased FT4, increased thyroid hormone binding ratio, decreased TSH

Answer 7

c. Decreased FT4, decreased thyroid hormone binding ratio, increased TSH

Question 8

Which statement best describes the relationship between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in cases of dysmenorrhea?
a. Increases in both hormones and a decrease in estrogen signal a pituitary cause of ovarian failure
b. Both are usually increased when there is
pituitary adenoma
c. In menopause, the LH level at the midcycle
peak is higher than the level of FSH
d. Both hormones normally peak 1–2 days before ovulation

Answer 8

b. Both are usually increased when there is
pituitary adenoma

Question 9

Which of the following conditions will increase total T4 by increasing TBG?
a. Anabolic steroid use
b. Pregnancy
c. Acute illness
d. Nephrotic syndrome

Answer 9

b. Pregnancy