Principles of Wound Healing

Question 1

Open Wound

Answer 1

Disruption of the skin or mucous membrane

Question 2

Closed Wound

Answer 2

Superficial layer is still intact and protects the wound against contamination

Question 3

Clean Wounds

Answer 3

Non-traumatic
Do not involve resp, oropharyngel, GI, or UG tracts
No visible contamination
Within 0-6 hours after wounding

Question 4

Clean-Contaminated Wounds

Answer 4

Non-traumatic
resp, oropharyngel, GI, or UG tracts are opened with spillage of contents
Clean wounds w drain placed
Small breaches in aseptic technique
0-6hrs after surgery

Question 5

Contaminated Wounds

Answer 5

Traumatic
Inflammation without purulent exudate
Procedures contaminated with GI organs or infected urine
Serious breaches in aseptic technique
Less than 4-6 hours old

Question 6

Infected/Dirty Wounds

Answer 6

Traumatic
Obvious contamination or signs of infection with purulent exudate or necrotic tissue
Perforation of GI or UG organs, serious fecal contamination
More than 10^5 bacteria per gram of tissue
More than 4-6 hours old

Question 7

What are the healing stages?

Answer 7

Initial sealed by blood clot
Blood vessels
Blood clot replaced with fibrous tissue
Granulation tissue formation (wound contraction)
Tissue proliferation
Maturation

Question 8

What are the 4 wound healing phases?

Answer 8

Acute inflammatory phase
Debridement phase
Reparation or proliferation phase
Remodeling or maturation phase

Question 9

What are the 3 processes of the proliferation phase?

Answer 9

Granulation
Contraction
Epithelialization

Question 10

Chronic Wounds

Answer 10

Lack of progression through the 4 phases of wound healing
Different biochemical wound fluid than acute
Increased inflammatory mediators
Breakdown of matrix and granulation tissue
Must make them acute wounds again for healing

Question 11

Compare the healing times of different tissue types

Answer 11