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NASP CSP 2024 > Oncology > Flashcards

Oncology Flashcards

1
Q

Oncogene

A

“Gas Pedal”

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2
Q

Tumor Suppressor Gene

A

“Brakes”

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3
Q

Antimetabolites

A

Block DNA
replication

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4
Q

Topoisomerase Inhibitors

A

Prevent DNA uncoiling

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5
Q

Alkylating Agents

A

Interfere with
DNA base pairing

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6
Q

Breast CA Classes

A

CDK 4/6, HER2, PARP

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7
Q

Melanoma Classes

A

BRAF, MEK

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8
Q

Can bill under Part B

A

TMZ and Cape.

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9
Q

Everolimus MOA

A

mTOR Inh.

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10
Q

Alpelisib (Piqray) MOA

A

PI3K Inh. PLUS Fulvestrant

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11
Q

CDK 4/6 Inhibitors

A

Palbociclib (Ibrance), Ribo-. (Kisqali), Abema-. (Verzenio)

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12
Q

Capecitabine Keypoints

A

BBW: Bleeding risk w/ coumadin, D 1-14 of 21D cycle

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13
Q

Everolimus Keypoints

A

ATC plus Exemestane, HTN, BBW: Immunosuppresion, dexameth. for stomatitis, watch angioedema

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14
Q

Piqray Keypoints

A

ATC plus Fulvestrant, CF, Hyper glycemia

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15
Q

Ibrance/Kisqali Keypoints

A

Add AI or fulvestrant, x21d, monitor ANC (myelosuppression), No grapefruit

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16
Q

Verzenio Keypoints

A

ATC, Can add AI/Fulvestrant OR mono Tx at higher dose, Diarrhea common, No grapefruit

17
Q

HER2 Meds

A

Nerlynx, Tykerb, Tukysa

18
Q

Nerlynx Keypoints

A

Diarrhea 95% x56d, avoid grapefruit and antacids, CF

19
Q

Tykerb Keypoints

A

Hepatotoxicity, Empty stomach, no grapefruit

20
Q

Tukysa Keypoints

A

Hepatotoxicity

21
Q

PARP Inibitors

A

Talzenna (Br., Prost.), Lynparza (Br, Ovar., Prost., Pancreatic), Rubraca (Ovarian/Prostate), Zejula (Ovarian)

22
Q

Talzenna Keypoints

A

BRCA-Mutated, ATC, myelodysplastis syndrome

23
Q

Lynparza Keypoints

A

BRCA-Mutated, ATC, myelodysplastis syndrome

24
Q

Rubraca, Zejula, Lynparza Keypoints

A

Both Tx and maint in ovarian, myelodysplastic syndrome

25
Q

EGFR Inhibitor Class ADE’s

A

Rash, Ocular, ILD

26
Q

EGFR Inh. Meds

A

Tagrisso, Tarceva, Gilotrif, Iressa, Vizimpro

27
Q

Avoid tobacco with this EGFR

A

Tarceva

28
Q

Which 2 EGFR’s do NOT have PPI warnings?

A

Gilotrif, Iressa

29
Q

Gilotrif and Tarceva with or without food?

A

Without

30
Q

ALK Inhibitors (3-5% lung CA)

A

Xalkori, Zykadia, Alecensa, Alunbrig, Lorbrena

31
Q

Which ALK Inh. has loading dose?

A

Alunbrig

32
Q

Alk Inh. Class ADE’s

A

ILD, Cardiac

33
Q

Alk Inh. Keypoints

A

Xalkori-Vision disorders, Alecensa-Photosensitivity,

34
Q

ROS1 Inhibitors (1-2% Lung CA; Non-smokers)

A

Rozlytrek (CHF and bone Fx), Xalkori (ALK and ROS1 MOA)

35
Q

BRAF V600E Mutation

A

Mekinist, Tafinlar (Combo for lung): Pyrexia, cough, empty stomach

36
Q

NTRK Gene Fusion (<1% Lung CA)

A

Rozlytek, Vitrakvi

37
Q
A

NASP CSP 2024 (9 decks)

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