Sedatives/Anesthetics Flashcards
Definition of sedative/anesthetics (3 words)
sedatives/anxiolytics/hypnotics
GABA how many subunits?
5
Site for convulsant work on
Picrotoxin site
Steroid site these medications work here
Allopregnanolone anesthetics and anxiogenic
GABA site a medication works here
bicucline
Medications that work on the benzodiazepine site
Agonists (diazepam and zolpidem) and inverse agonist here, and antagonist
Orthosteric site of the gaba receptor
GABA binds at the orthosteric site on the GABAA receptor
Promote the gaba receptor
allopregnanolone, anesthetics, agonst (daizepam and zolpidem)
Inhibit the gaba receptor
inverse agonist, antagonists, bicucline, convulsants, anxiogenics
Benzo plus an opioid can cause
resp depression, coma, death
Midazolam can interact with
antifungals
Midazolam are prolonged with these conditions
obesity and decreased albumin levels
Lorazepam is preferred when
long term sedations >72 hours
Lorazepam is offered in these routes
oral im and iv
benzodiazepine withdrawal can occur ____ length of time
after 2 weeks of benzo use
symptoms of benzo withdrawal
insomnia, anxiety, inc hr, autonomic instability
to avoid benzo withdrawal
convert to longer acting agent to taper slowly
time frame for emergence of symptoms of benzo withdrawl
corresponds to the half life of the benzo
these medications do not stay in the tissues for a long time
etomidate, prop and ketamine
propofol is a ____ agonist
GABA agonist (inhibitory activity)
How does Propofol cross the BBB
Highly lipid solubility
ketamine can cause this state of anesthesia.
dissociative (eyes open talking moving but dissociated from pain)
Hemodynamic effect of ketamine
little* resp depression