wang

Question 1

etanercept

Answer 1

Enbrel, anti tnf alpha receptor

Question 2

infliximumab

Answer 2

remicade, anti tnf mab chimeric

Question 3

adalimumab

Answer 3

humaira, anti-tnf alpha mab (human)

Question 4

certolizumab pegol

Answer 4

cimizia, pegulated anti tnf alpha mab

Question 5

ustekinumab

Answer 5

stellara, IL-12/23 inhibitor

Question 6

secukinumab

Answer 6

cosentyx, Il-17, contraidicated for IBD

Question 7

ixekizumab

Answer 7

taitz, IL-17, contrindicated for IBD

Question 8

broadalumab

Answer 8

siliq, Il-17, BBW for suicide and has a rems, contraindicated for IBD

Question 9

Guselkumab

Answer 9

tremfya, IL-23 inhibitor

Question 10

tildrakizumab

Answer 10

llumya, IL-23 inhibitor

Question 11

risankizumab

Answer 11

skyrizi, IL-23 inhibitor

Question 12

IL-23 inhibitor benefits

Answer 12

convenient infrequent dosing, and they are more safe and efficacious than a IL-12/23 inhibitor and TNF alpha inhibitor

Question 13

methotrexate

Answer 13

• dihydrofolate reductase inhibitor
• less effective than tnf alpha inhibitors
• once a week dosing
• ADR: MYLOSUPRESSION, RENAL AND HEPATIC TOXICITY
• BBW: pregnancy category X

Question 14

Acitretin

Answer 14

brand: Soriatane
- less effective than MTX and cyclosporine as monotherapy
- adjuct woth phototherapy
- slow can take 3-6 months
- Potent teratogen (don’t be preggo)

Question 15

Ampremialst

Answer 15

Brand; Otezla
- PDE4 inhibitor, so increase in Camp
- oral
- Safety: GI problems in 15-20% so initial dose titration over 5 days.

Question 16

Cyclosporine

Answer 16

• calcineurin inhibitor
• NO MYLOSUPRESSION OR HEPATOXICTY
• cannot use long term
• rapid onset and 80-90% improvement in 12-10 weeks.

Question 17

roflumilast

Answer 17

Brand: Zoryve
- TOPICAL
- PDE-4 inhibitor
- once a day for 8 weeks

Question 18

Anthralin

Answer 18

brand: Zithranol
- TOPICAL
- avoid application to face and skin folds
- once a day,apply thick layer and then take it off in 2 hours
- polycyclic aromatic hydrocarbon

Question 19

taparinof 1% cream

Answer 19

brand: Vtama
- TOPICAL
- actication of the ahr receptor downregulates Il-17
once daily for 12 weeks
after cessation maintain for 4 months

Question 20

tazarotene

Answer 20

brand: tazorac
- TOPICAL retinoid
- 0.05 and 0.1% gel and cream
- downregulates expression of inflammatory markers and inhbits proliferation of keratinocytes
- AVOID IN PREGNANCY
- ONCE A DAY