organ systems associated with the immune response Flashcards
1
Q
what organs are responsible for lymphocyte production?
A
primary lymphoid organs
2
Q
where are t lymphocytes produced
A
produced in the bone marrow but then migrate to the thymus for maturation/selection
3
Q
why do 98% of immature thymocytes die
A
as undergo positive and negative selection
4
Q
what is positive selection
A
must be able to bind to MHC
5
Q
negative selection
A
must not bind to self antigens
6
Q
where are b lymphocytes produced
A
produced and selected in the bone marrow
7
Q
what happens in the secondary lymphoid organs?
A
region where lymphocytes come into 1st contact with foreign antigen
undergo clonal expansion
mature into effector cells
8
Q
what are lymph nodes connected to
A
lymphatic vessels
9
Q
what is the spleen connected to
A
blood vessels
