Drug Classes

Question 1

Cholinergic Receptor Agonists direct vs indirect

Answer 1

direct:
- choline esters
- Plant alkaloids

indirect:
- cholinesterase inhibitors

Question 2

Cholinergic Receptor Agonists: Choline esters

Answer 2

Direct cholinergic agonists

• ACh
• Carbachol: chronic open angle glaucoma, miosis during ophthalmic surgery
• Bethanechol: urinary retention post op
• methacholine: not commercially available

Question 3

Cholinergic Receptor Agonists: Plant alkaloids

Answer 3

-nicotine: smoke cessaton
- pilocarpine: glaucoma to decrease IOP
- Cevimeline: dry mouth with Sjogren’s syndrome
- muscarine - no medical use

Question 4

Cholinesterase inhibitors: reversible

Answer 4

-Donepezil: alzheimer Ds
-Edrophonium: Dx - myasthenia gravis
-Neostigmine: Tx - myasthenia gravis; antidote for skeletal muscle relaxants
-Pyridostigmine: Tx - myasthenia gravis
-Physiostigmine: Tx - overdose of anticholinergic effects drugs

DENPP

Question 5

Cholinesterase inhibitors: irreversible

Answer 5

-ecothiophate: chronic refractory glaucoma tx
-pesticides
-soman: chemical warfare