Protein Domains

Question 1

What does the SH3 domain bind to?

Answer 1

proline-rich peptides

Question 2

What does the SH2 domain bind to?

Answer 2

phosphotyrosine-containing target peptides

Question 3

What does the PH domain bind to?

Answer 3

phosphorylated inositol phospholipid

lipids

Question 4

What does the PTB domain bind to?

Answer 4

phosphotyrosine-containing target peptides

Question 5

Explain the role of SH2 domain in protein function.

Answer 5

They bind to phosphorylated tyrosine residues

Question 6

What is the PX domain’s binding function?

Answer 6

PI binding

Question 7

What is the PLD domain’s binding function?

Answer 7

catalytic activity

Question 8

What is the PH domain’s binding function?

Answer 8

role in targeting enzyme to locations within the cell

Question 9

What does the FYVE domain bind to?

Answer 9

PI(3)P

phosphatidylinositol 3-phosphate

Question 10

What does the PH domain bind to?

Answer 10

specific phosphoinositides such as phosphatidylinositol- 4,5-bisphosphate (PI(4,5)P)
PI-3
4-P2
PI-3,4,5-P3.

Question 11

What does the PB1 domain bind to?

Answer 11

Cdc24, p40Phox, PKCZ, etc..

Question 12

What does the PDZ domain bind to?

Answer 12

lipids and C-terminal peptides