9/02/24 (psych 1)

Question 1

How does ondansetron work?

Answer 1

5-HT3 receptors antagonist

Question 2

How does St John’s Wort affect the COCP?

Answer 2

It reduces its effectiveness

Question 3

What drugs shouldn’t be taken in combination with SSRIs?

Answer 3

• MAOIs (e.g. selegiline) and triptans
• Increase risk of serotonin syndrome

Question 4

What are the signs of SSRI discontinuation syndrome?

Answer 4

Dizziness, electric shock sensations and anxiety

Question 5

Signs of serotonin syndrome?

Answer 5

• Hyperreflexia, myoclonus and rigidity
• Hyperthermia and sweating
• Confusion

Question 6

What drug is given for agitation in palliative care?

Answer 6

Haloperidol

Question 7

What liver disease is seen in COCP use?

Answer 7

Drug induced cholestasis

Question 7

What is the most effective antipsychotic for dealing with negative symptoms of schizophrenia?

Answer 7

Clozapine

Question 8

What is the first line medical therapy for diabetic neuropathy?

Answer 8

Duloxetine

Question 9

What antibiotic is associated with development of erythema multiform?

Answer 9

Co-amoxiclav (aminopenicillins)

Question 10

What are the signs and treatment of restless leg syndrome?

Answer 10

• Signs: uncontrollable urge to move legs (worse at night), parathaesias (crawling, throbbing), periodic limb movements of sleep
• Treatment is ropinerole

Question 11

What drug can cause haematological toxicity when co-prescribed with methotrexate?

Answer 11

Trimethoprim

Question 12

Signs of raised prolactin?

Answer 12

• Men: impotence, loss of libido galactorrhoea
• Women: Amenorrhoea, galactorrhea