Uveitis Flashcards
Anterior uveitis involves inflammation of the anterior uvea, also called the vascular tunic/layer. The uvea is composed of 3 parts:
- iris
- choroid
- ciliary body
What is the incidence of uveitis?
1 - 4 cases per 100,000
2 - 40.00 cases per 100,000
3 - 400 cases per 100,000
4 - 4000 cases per 100,000
2 - 40.00 cases per 100,000
Equally likely in males and females
What is age does the peak incidence of uveitis typically occur?
1 - >65
2 - 40-50
3 - 30-40
4 - 20-30
3 - 30-40
The choroid is part of the uvea. Which 2 layers of the eye does the choroid sit between?
1 - lens and sclera
2 - sclera and retina
3 - cornea and lens
4 - retina and lens
2 - sclera and retina
There are 3 main types of uveitis:
- anterior uveitis
- posterior uveitis
- intermediate uveitis
Which of these 3 accounts for 75-90% of uveitis?
- anterior uveitis
Is uveitis typically uni or bilateral?
- unilateral
Anterior uveitis can be caused by a number of factors, but which is often the most common?
1 - infection
2 - idiopathic
3 - autoimmune
4 - ischaemia or malignancy
5 - trauma
3 - autoimmune
Typically the anterior chamber becomes infiltrated by neutrophils, lymphocytes and macrophages.
Hypopyon refers to a fluid collection containing inflammatory cells seen at the bottom of the anterior chamber on inspection.
Autoimmune causes are among the most common causes of uveitis. Which of the following autoimmune conditions is NOT typically associated with uveitis?
1 - Seronegative ankylosing spondylitis
2 - reactive arthritis
3 - T1DM
4 - inflammatory bowel disease
5 - sarcoidosis
6 - Behçet’s disease
3 - T1DM
Which major histocompatibility complex (MHC) molecule present in a number of conditions is linked to causing uveitis?
1 - HLA-B27
2 - HLA-DRB1
3 - HLA-DQA1
4 - HLD-DR2
1 - HLA-B27
Common in ankylosing spondylitis and reactive arthritis
Which of the following pathogens has the weakest, if any link with uveitis?
1 - herpes simplex virus (HSV)
2 - hepatitis B
3 - varicella-zoster virus (VZV)
4 - cytomegalovirus (CMV)
2 - hepatitis B
Does uveitis typically have an insidious onset or acute onset?
- acute
In uveitis, is there any change in visual acuity?
- yes
Typically because of the Hypopyon refers to a fluid collection containing inflammatory cells seen at the bottom of the anterior chamber on inspection.
Patients typically present with which of the following if they have uveitis?
1 - Painful red eye (typically a dull, aching pain)
2 - Reduced visual acuity
3 - Photophobia (due to ciliary muscle spasm)
4 - Excessive lacrimation (tear production)
5 - all of the above
5 - all of the above
When suspecting a patient uveitis, which of the following examination findings would not likely be present?
1 - Ciliary flush
2 - Dilated but unresponsive pupil
3 - Abnormally shaped pupil
4 - Hypopyon (inflammatory cells collected as a white fluid in the anterior chamber)
2 - Dilated but unresponsive pupil
Typically miosis, a constricted pupil is present due to sphincter muscle contraction
Ciliary flush = ring of red spreading from the cornea outwards
Abnormally shaped pupil is due to posterior synechiae (adhesions) pulling the iris into abnormal shapes
What is the term used to describe an abnormally shaped pupil in uveitis?
1 - episcleritis
2 - dendritic ulcer
3 - posterior synechiae
4 - nodular scleritis
3 - posterior synechiae Iris
Caused by attachments to the lens known as posterior synechiae gives rise to irregular shaped iris
Depending on the cause of the uveitis, a variety of tests need to be performed following an eye examination. Which of the following would NOT typically be performed?
1 - antibody testing
2 - serologic tests for STIs
3 - quantiFERON-TB Gold for tuberculosis
4 - autoimmune markers, such as HLA-B27, antinuclear antibody (ANA), and rheumatoid factor
5 - eye biopsy
5 - eye biopsy
Not performed
