Vasopressors/ Sympathomimetics Flashcards
vasopressors are NOT a replacement for
Adequate volume
Blood
TOO MUCH ANESTHESIA
ephedrine class
Mixed - acting synthetic non-catecholamine sympathomimetic
ephedrine indirect effects
Ephedrine at Alpha-1 and Beta-1 receptors displaces norepinephrine presynaptic vesicles
what occurs when norepinephrine is released
activates the postsynaptic receptors to cause arterial and venous vasoconstriction and increased myocardial contraction
ephedrine direct effect
directly stimulates β- 2
ephedrine effects
Increased heart rate, cardiac output , and some SVR increase
what is ephedrine good for
bradycardia and hypotension
α-1 receptors
walls of blood vessels
urinary retention
mydriasis (pupil dilation)
ejaculation
α-2 receptors
pre-synaptic neuron
β-1 effects
heart and kidneys
β-2 receptors
smooth muscle relaxation
lungs, vessels, GI tract, bladder, uterus, liver
β-3 receptors
adipose tissue, bladder
ephedrine uses
increases BP/HR, CO and contractility, PONV, bronchodilator effect
ephedrine in OB
can cause fetal tachycardia and acidosis which was associated with lower umbilical artery pH at delivery
ephedrine contraindicaitons (med and condition)
MAO inhibitors
pheochromocytoma