Antihypertensives/Beta Blockers Flashcards

(51 cards)

1
Q

labetalol nonselective β-1 effects

A

decreases HR and contractiliity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

labetalol nonselective β-2 effects

A

vasodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

where is labetalol selective

A

α-1 adrenergic agoist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what does labetalol cause at α-1 receptors

A

arterial vasodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

labetalol blockade ratio

A

1 α to 7 β

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

labetalol uses

A

acute and chronic HTN in pregnant pts, treat increases in BP and HR from stimulation (intubation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how does labetalol cause ↓ BP

A

decreased CO and PVR, can depress cardiac contractility, minimally affects CBP or ICP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

when is labetalol contraindicated

A

bronchospastic disease → impaired cardiac conduction or underlying resting bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

labetalol dose

A

5-20 mg boluses IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

labetalol onset

A

1-2 min

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

labetalol duration

A

up to 6 hrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

esmolol mechanism of action

A

Rapid-onset and short-acting selective Beta-1 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

esmolol uses

A

treat perioperative tachycardia, pre-treatment during intubation/extubation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

esmolol ♡ effects

A

Decrease in HR, myocardial contractility, CO , and some decrease in BP, with no rebound effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

when is esmolol contraindicated

A

bradycardia
heart block
cardiogenic shock
heart failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

esmolol dose

A

10mg boluses IV
infusions of 50 mcq/kg/min after a .5mg/kg bolus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

esmolol onset and duration

A

rapid onset; 10-15 min duration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

how is esmolol metabolized

A

by plasma esterases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

propranolol class

A

non selective β-1 and β-2 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

propranolol uses

A

HTN, angina, acute MI, pheochromocytoma, treat anxiety and panic attacks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

how does propranolol work

A

Decreases BP due to decrease in myocardial contractility, HR, CO therefore decrease in myocardial oxygen demand

22
Q

propranolol cautions in

A

bronchospastic disease, AV block, and bradycardia

23
Q

propranolol dose

A

1-3 mg IV (no more than 1 mg/min), titrated to effect

24
Q

propranolol onset

25
propranolol duration
4-6 hours
26
metoprolol class
selective β-1 adrenergic receptor antagonist
27
metoprolol mechanism of action
prevents inotropic and chronotropic responses to β- stimulation
28
metoprolol uses
rapid HR and contractility control, CO and therefore decrease BP, treatment for MI
29
metoprolol dose
1-5 mg IV up to 15 mg
30
metoprolol half life
3-4 hours
31
vasopressin is also known as
antidiuretic hormone
32
where is vasopressin released in the body
the posterior pituitary
33
vasopressin receptors and effects
V1- CV effects V2- renal V3- pituitary receptors
34
vasopressin uses
cardiac arrest (removed from ACLS algorithm), sepsis, shock and hypotension secondary to ACE inhibitors refractory to catecholamines or sympathomimetics
35
vasopressin dose
mix I0/20 units/ml in a 10/20 ml syringe to get 1 unit/mL concentration
36
vasopressin dose
1-2 unit bolus
37
vasopressin is a ____________
potent vasoconstrictor (arterial and mesenteric)
38
hydralazine mechanism of action
direct systemic arterial vasodilator
39
how does hydralazine work
causes relaxation of arterial smooth muscle; blocks calcium release from sarcoplasmic reticulum; decreases BP with **increase** in HR, SV, and cardiac output
40
hydralazine uses
HTN, heart failure, eclampsia
41
hydralazine can cause
increased ICP
42
when is hydralazine contraindicated
in coronary artery disease
43
hydralazine dose
2.5-5 mg IV titrated q 20-30 min
44
hydralazine onset
15-30 min
45
hydralazine duration
4-6 hrs
46
which drug is contraindicated in bronchospastic disease?
labetalol
47
which drug is used to treat pheochromocytoma?
propanolol
48
which drug should be used carefully in bronchospastic disease?
propanolol
49
which drug can be used for hypotension secondary to ACE inhibitors refractory to catecholamines or sympathomimetics?
vasopressin
50
which drug decreases blood pressure with an increase in HR
hydralazine
51
which drug is contraindicated in CAD
hydralazine