Antihypertensives/Beta Blockers Flashcards
(51 cards)
labetalol nonselective β-1 effects
decreases HR and contractiliity
labetalol nonselective β-2 effects
vasodilation
where is labetalol selective
α-1 adrenergic agoist
what does labetalol cause at α-1 receptors
arterial vasodilation
labetalol blockade ratio
1 α to 7 β
labetalol uses
acute and chronic HTN in pregnant pts, treat increases in BP and HR from stimulation (intubation)
how does labetalol cause ↓ BP
decreased CO and PVR, can depress cardiac contractility, minimally affects CBP or ICP
when is labetalol contraindicated
bronchospastic disease → impaired cardiac conduction or underlying resting bradycardia
labetalol dose
5-20 mg boluses IV
labetalol onset
1-2 min
labetalol duration
up to 6 hrs
esmolol mechanism of action
Rapid-onset and short-acting selective Beta-1 antagonist
esmolol uses
treat perioperative tachycardia, pre-treatment during intubation/extubation
esmolol ♡ effects
Decrease in HR, myocardial contractility, CO , and some decrease in BP, with no rebound effects
when is esmolol contraindicated
bradycardia
heart block
cardiogenic shock
heart failure
esmolol dose
10mg boluses IV
infusions of 50 mcq/kg/min after a .5mg/kg bolus
esmolol onset and duration
rapid onset; 10-15 min duration
how is esmolol metabolized
by plasma esterases
propranolol class
non selective β-1 and β-2 antagonist
propranolol uses
HTN, angina, acute MI, pheochromocytoma, treat anxiety and panic attacks
how does propranolol work
Decreases BP due to decrease in myocardial contractility, HR, CO therefore decrease in myocardial oxygen demand
propranolol cautions in
bronchospastic disease, AV block, and bradycardia
propranolol dose
1-3 mg IV (no more than 1 mg/min), titrated to effect
propranolol onset
2-3 min