Steps Of Endochondrial Ossification

Question 1

Step 1

Answer 1

Mesoderm cells develop and differentiate into mesenchymal cells

Question 2

Step 2

Answer 2

Mesenchymal cells migrate then aggregate-(gather together)at future bone site to form its shape

Question 3

Step 3

Answer 3

After Mesenchymal cells have aggregated to site of future bone, they then differentiate into CHONDroblasts-that secrete Cartilage ECM

Question 4

Step 4

Answer 4

After chondroblasts have secreted ECM, the ECM hardens to cartilage which is surrounded by a fibrous perichondrium(covering )

Question 5

Step 5

Answer 5

After Cartillage ECM is solidified the chondroblast becomes trapped. TheY are now known From being chondroblasts to CHONDROCYTES.

Question 6

Step 6- Hypertrophy- death & Calcification

Answer 6

Chondrocytes enlarge to the point where single nuclei can’t support cell anymore

Question 7

Step 7-Primary Ossification center

Answer 7

Space created in center of bone after hardening and drying out of CHONDROCYTES after death

Question 8

Step 8

Answer 8

Nutrient Artey invades the primary marrow cavity