Haemophilia

Question 1

Cause of Haemophilia A and B?

Answer 1

A- deficiency of factor VIII
B- deficiency of factor IX

X linked recessive diseases

Question 2

Features of haemophilia?

Answer 2

Excessive bleeding or spontaneous bleeding
In childhood present with haemorrhage, haematomas and cord bleeding

Question 3

Diagnosis of haemophilia?

Answer 3

Bleedign scores, coagulation factor assays and genetic testing

Question 4

Management of haemophilia?

Answer 4

Clotting factors VIII or IX can be given by intravenous infusion
Complication of this treatment is the formation of antibodies (called ihbitors) causing it to become ineffective