Investigation of Haemostasis

Question 1

What is meant by primary haemostasis?

Question 2

does prothrombin time assess the extrinsic or intrinsic pathway

Answer 2

extrinsic (TF, factor VII)

Question 3

does APTT assess the extrinsic or intrinsic pathway

Answer 3

intrinsic (factors XII, XI, IX, and VIII)

Question 4

what do you need for primary haemostasis

Answer 4

platelets
von willebrand factor
collagen

Question 5

features of a primary haemostasis problem

Answer 5

• excess bruising
• menorrhagia
• petechiae, purpura
• epistaxis
• blood blisters in mouth

Question 6

features of a secondary haemostasis problem

Answer 6

intramuscular bleeds
joint bleeding
bleeding after operations

Question 7

what kind of problems could cause primary haemostasis problem

Answer 7

• low platelet count
• von willebrand
• vascular problems, problem with collagen

Question 8

normal prothrombin time

Answer 8

10-14.5 seconds

Question 9

normal Activated partial thromboplastin time

Answer 9

21-35 seconds

Question 10

factor VIII deficiency is aka

Answer 10

haemophilia A

Question 11

factor IX deficiency is aka

Answer 11

haemophilia B

Question 12

treatment for von willebrand disease

Answer 12

desmopressin - itworks quick, subcutaneous

Question 13

clotting factor II is also known as

Answer 13

prothrombin

Question 14

what test is used to monitor warfarin

Answer 14

INR

Question 15

lack of fibrinogen is a late sign of DIC, true or false

Answer 15

true

Question 16

what do we give if fibrinogen low

Answer 16

cryoprecipitate (get some in FFP but higher concentration is cryoprecipitate)

Question 17

cornerstone treatment of DIC

Answer 17

treat underlying cause (e.g. fix the haemorrhage, antibiotics etc)