COMMON VARIABLE IMMUNODEFICIENCY Flashcards
1
Q
Which is the most common primary immunodeficiency?
A
Common variable immunodeficiency
2
Q
What happens in common variable immunodeficiency?
A
Several mutations in BAFFR and TACI
↳ B cell unable to differentiate into antibody producing plasma cells ↳ Decrease only in plasma cells
3
Q
Pathophysiology
A
B cell fenotypically normal
↳ Unable to differentiate into Ig-producing cells (plasma cells)
↳ Low immunoglobulins of all classes
4
Q
Clinical manifestations
A
-Recurrent infections of respiratory and GI tracts
-Elevated risk malignancies of lymphomas
**-Antibody response to vaccines is attenuated or absent **
5
Q
Diagnosis
A
-Normal B cells with low levels of plasma cells
-Low levels of immunoglobulins IgA and IgG
-Normal or elevated IgM
