Lecture 10 Flashcards
What has to happen to polarized structure for cytokinesis to occur
Depolymerize
What needs to happen to cell after division
Needs to go from nonpolar to polar to support function
Dense material left after cytokinesis is the
Midbody, leaves a marker on both cell
The midbody acts as
A landmark for polarization in new cells
Cell polarization-post cytokinesis
-Apical-basal polarity
-Cell-cell communication
-Cell migration
Apical-basal polarity (simple) and example
Molecules need to be transported in one direction -epithelial cells
Actin filaments bundle into _______ to _______
Microvilli, increase cell surface area - (these anchor on adherent junctions that anchors each cell to the next)
IFs anchor actin in the cell cortex with _________ that _____
desmosomes/hemidesmosomes, that connect cell w other cell and ECM
Microtubules polymerize from _____ to _________ for what?
Apical to basal, directionality for transport of intracellular components
In the polarized cell, actin filaments are
highly localized into filopodia and lamelopodia
Planar cell polarity
Orients polarity axis in relation to neighbours and basal lamina
2 key regulators of actin assembly and what do they bind to
Rac and Cdc42 - specific binding sites on Par3/6 and aPXC
Par3 and 6 are what type of proteins and what domain to they contain
Scaffold proteins, PDZ domains
What do PDZ domains do/give in the cell
Give localization within cell
CRB
transmembrane protein and tumor supprsssor active during transformation and progression of mammalian epi cells
