Chaki et al., 2015 paper Flashcards
What receptor dysfunction is implicated in schizophrenia according to the paper?
NMDAR
How does glycine function in the context of NMDA receptors?
Glycine acts as a co-agonist, enhancing NMDA receptor function.
What is the mechanism of action of TASP0315003?
TASP0315003 inhibits the reuptake of glycine, leading to increased synaptic glycine levels.
In animal models, how did TASP0315003 affect performance in tasks related to social behavior?
TASP0315003 improved performance in the social recognition test.
What potential advantage does TASP0315003 have compared to some current antipsychotics?
TASP0315003 may have fewer side effects like sedation and motor dysfunction.
Based on the paper, what are the two main areas of potential benefit for TASP0315003 as a treatment for schizophrenia?
Cognitive dysfunction and negative symptoms
Did the study directly measure the effect of TASP0315003 on NMDA receptor function in the animals?
No, the study focused on behavioral improvements in animal models.
Is TASP0315003 currently an approved medication for schizophrenia?
No, the study was in animal models; further research is needed.
figure 1
structure of TASP0315003
figure 2
TASP0315003 significantly increases glycine concentration in the CSF of rats
Figure 3 (novel objection recognition test) - cognition
MK801 significantly decreases time spent exploring new objects
TASP0315003 significantly improved the MK801 induced cognitive deficits
Figure 4
clozapine and TASP0315003 had a significantly shorter RID
when unfamiliar rats shown to exposed rat - TASP0315003 had no affect on RID (unlike risperidone)
Figure 5
MK801 induced memory impairment
MK801 impaired social memory
unfamilar rat - TASP0315003 has no effect (no RID reduction)
Figure 6 (PCP)
risperidone and TASP0315003 significantly attenuated effect of PCP
only TASP0315003 had no effect on social interaction
Figure 7 (forced swimming)
to test antidepressant effects
TASP0315003 and fluvoxamine significantly reduced immobility
