Impaired or Defective Production of Anemias/Classification of Anemia according to CAUSE

Question 1

➢ Most common form of anemia
➢ Microcytic/hypochromic anemia
➢ Serum iron, ferritin, hemoglobin/hematocrit, RBC indices,
reticulocyte count- LOW
➢ RDW and TIBC- HIGH

A. Anemia of chronic disease (ACD)
B. Iron deficiency anemia (IDA)
C. Sideroblastic anemia

Answer 1

B. Iron deficiency anemia (IDA)

Question 2

➢ Inability to use available normal RBC
➢ Impaired release of storage iron associated with increased
HEPCIDIN levels
➢ Normocytic/normochromic anemia, or slightly
microcytic/hypochromic anemia
➢ ESR, ferritin- INCREASED
➢ Serum iron and TIBC – DECREASED
➢ Associated with persistent infections, chronic inflammatory
disorders

A. Iron deficiency anemia (IDA)
B. Anemia of chronic disease (ACD)
C. Sideroblastic anemia

Answer 2

B. Anemia of chronic disease (ACD

Question 3

➢ Caused by blocks on the protoporphyrin pathway resulting in defective
➢ hemoglobin synthesis and iron overload
➢ Excess iron accumulates in the mitochondrial region of
immature erythrocytes
➢ (ringed sideroblasts)
➢ Two RBC populations (dimorphic) are seen
➢ Microcytic/hypochromic anemia
➢ Ferritin and serum iron- INCREASED
➢ TIBC – DECREASED

Answer 3

Sideroblastic

Question 4

➢ Multiple blocks in the protoporphyrin pathway
➢ Normocytic/normochromic anemia with characteristic course basophilic stippling

A. Lead poisoning
B.megablastic anema

Answer 4

A

Question 5

➢ Group of inherited disorders characterized by a block in the
➢ protoporphyrin pathway
➢ Heme precursors before the block accumulate in the tissues,
and large
➢ amounts are excreted in urine/feces
➢ Photosensitivity, abdominal pain, CNS disorders
➢ Hematologic findings are insignificant

A. Lead poisoning
B. Anemia of chronic disease (ACD)
C. Porphyria
B.

Answer 5

C. Porphyria

Question 6

➢ Defective DNA synthesis causes abnormal nuclear maturation; RNA synthesis is normal, so the cytoplasm is not affected
➢ Nucleus matures slower than the cytoplasm (asynchronism)
➢ Caused by either Vitamin B12 deficiency or folic acid
deficiency
➢ Macrocytic/normochromic anemia

A. Aplastic anemia
B.megaloblastic
C. Myelophthisic (Bone marrow replacement) anemia

Answer 6

B.megaloblastic

Question 7

➢ Bone marrow failure
➢ Decrease in hemoglobin/hematocrit and reticulocytes ➢ Normocytic/Normochromic anemia

A. Aplastic anemia
B.megaloblastic
C. Myelophthisic (Bone marrow replacement) anemia

Answer 7

A. Aplastic

Question 8

➢ Hypo-proliferative anemia caused by replacement of bone marrow hematopoietic cells by malignant cells or fibrotic tissue
➢ Normocytic/normochromic anemia

A. Aplastic anemia
B.megaloblastic
C. Myelophthisic (Bone marrow replacement) anemia

Answer 8

C.myelophthistic