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Top Drawer > Mechanisms > Flashcards

Mechanisms Flashcards

1
Q

propofol mechanism of action

A

stimulation of GABA α receptors

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2
Q

ketamine mechanism of action

A

noncompetitive NMDA receptor antagonist that blocks glutamate

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3
Q

thiopental mechanism of action

A

short-acting barbiturate, activated GABA

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4
Q

etomidate mechanism of action

A

GABA agonist

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5
Q

dexmedetomidine mechanism of action

A

highly potent central acting α-2 adrenergic agonist

inhibits release of norepinephrine

decreases cAMP

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6
Q

methohexital mechanism of action

A

enhances GABA

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7
Q

succinylcholine mechanism of action

A

binds to 2 alpha subunits of nicotinic cholinergic receptors

allows Na and Ca influx and K efflux

mimics Acetylcholine

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8
Q

neostigmine mechanism of action

A

inhibits hydrolysis of acetylcholine by AchE

acetylcholinesterase inhibitor

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9
Q

edrophonium mechanism of action

A

inhibits hydrolysis of Acetylcholine by AchE

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10
Q

physostigmine mechanism of action

A

inhibits cholinesterase

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11
Q

sugammadex mechanism of action

A

selective relaxant binding agent that encapsulates roc, vecuronium, or pancuronium

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12
Q

atropine mechanism of action

A

competitive acetylcholine antagonist at central and peripheral receptors

antimuscarinic, naturally occurring alkaloid

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13
Q

glycopyrrolate mechanism of action

A

competitive acetylcholine antagonist, synthetic antimuscarinic

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14
Q

scopolamine mechanism of action

A

competitive antagonist of acetylcholine at muscarinic receptors

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15
Q

ephedrine mechanism of action

A

sympathomimetic

directly stimulates α-1, β-1, and some β-2

indirectly stimulates endogenous release of norepinephrine or inhibits uptake

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16
Q

phenylephrine mechanism of action

A

directly stimulates α-1, minimal stimulation of α-2 or β-1 at hight doses

17
Q

labetalol mechanism of action

A

nonselective β-1 and β-2 with selective α-1 adrenergic antagonist

considered a β- blocker

18
Q

esmolol mechanism of action

A

cardio-selective β-1 antagonist

19
Q

propranolol mechanism of action

A

non-selective β-1 and β-2 antagonism

20
Q

metoprolol mechanism of action

A

selective β-1 receptor blocker

21
Q

hydralazine mechanism of action

A

blocks Ca release from the sarcoplasmic reticulum

22
Q

metoclopramide mechanism of action

A

D2 agonist in thechemoreceptor trigger zone

23
Q

pepcid mechanism of action

A

H2 receptor antagonist

24
Q

ondansetron mechanism of action

A

selective 5-HT3 receptor antagonist

25
Q

promethazine mechanism of action

A

phenothiazine, H1 receptor antagonist, anticholinergic action, D2 antagonist in CHEMORECEPTOR TRIGGER ZONE

26
Q

hydroxizine mechanism of action

A

blocks acetylcholine in the vestibular apparatus, blocks H1 receptors in the solitary track

27
Q

oxytocin mechanism of action

A

indirectly ↑ intracellular Calcium

28
Q

methylergonovine (Methergine) mechanism of action

A

semisynthetic ergot alkaloid

arterial vasoconstriction by alpha stimulation

29
Q

carboprost (Hemabate) mechanism of action

A

a synthetic analog of prostaglandin F2

30
Q

cytotec mechanism of action

A

synthetic prostaglandin E1

31
Q

mag sulfate mechanism of action

A

inhibition of acetylcholine release at the neuromuscular junction

32
Q

labetalol mechanism of action

A

combined α- and β- antagonist

33
Q

nipride mechanism of action

A

potent arteriolar dilator

34
Q

nitroprusside mechanism of action

A

venodilator to ↓ cardiac filling

35
Q

ketorolac mechanism of action

A

NSAID

non-selective Cox 1 and Cox 2 inhibitor

36
Q

ofirmev mechanism of action

A

non -opioid

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