Exam 3 Flashcards

1
Q

List the 6 categories of drugs used to treat high cholesterol / high triglycerides

A
HMG Co-A Reductase inhibitors (Statins)
Bile acid binding resins (Chole/cole)
Nicotinic acid (niacin)
fibrinic acids (fibs)
cholesterol absorption inhibitors 
Omega 3 fatty acids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
What category are these drugs?
What do they do?
AtorvaSTATIN (Lipitor)
FluvaSTATIN (Lescol)
PravaSTATIN (Pravachol)
SimvaSTATIN (Zocor)
A
  • HMG Co-A Reductase inhibitors
  • decrease LDL, total cholesterol, triglycerides
  • increases HDL
  • slows CAD by stabilizing plaque & reducing inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Best time to take a statin?
What food should not be taken with statins?
4 major side effects pt. needs to watch for are:
Safe in pregnancy?

A

-night
-grapefruit
-1. myopathy (muscle soreness or weakness)
-2. hepatotoxicity (fever/dark brown urine)
1-2% of pt. develop this
-3. myositis (inflammation)
-4. rhabdomyolysis (chunks of muscle breakdown, clog kidneys - renal failure) (bc inhibs Co Q10)
- NOT safe in pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What lab test is imp when taking statins?

A

-LFT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

1 most common drug prescribed in the US?

A

AtorvaSTATIN (Lipitor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Why/how do HMG Co-A reductase inhibitors reduce cholesterol?

A

hemoglobin Co-A reductase is the enzyme that allows synthesis of cholesterol in the liver. Inhibiting this enzyme decreases cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q
What category are these drugs?
What do they do?
CHOLEstyramine (Questran)
COLEstipol (....)
COLEsevelam (Welchol)
A
  • Bile acid binding resins

- lowers LDL (not 1st line)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
--What Class are these---
Atorvastatin* (Lipitor) 
Fluvastatin (lescol)
Lovastatin (mevacor)
Pravastatin (pravachol)
Simvastatin (zocor)
A

HMG Co-A reductase inhibitors (“statins”)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

–What Class are these—
Cholestyramine (Questran)
Colestipol Colesevelam (Welchol)

A

Bile acid-binding resins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

–What Class are these—

Niacin (Niaspan or Slo-Niacin)

A

Nicotinic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

–What Class are these—
Gemfibrozil (Lopid)
Fenfibrate (Tricor)

A

Fibric acid derivatives

Or Fibrinic acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

–What Class are these—

Ezetimibe (Zetia)

A

Cholesterol absorption inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

–What Class are these—

Fish oil Omacar

A

Omega 3 fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q
--What Class are these---
Enalapril (Vasotec)
Ramipril (Altace)
Captopril (Capoten)
Lisinopril (Zestril/prinivil)
Trandolapril (Mavik)
Quinapril (Accupril)
Benazepril (Lotensin)
A

Angiotension Converting Enzyme Inhibitor (ACE-1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

–What Class are these—
Methydopa (Aldomet)
Catapress (Clonidine)
Guanfacine (Tenex)

A

Alpha-2 receptor agonists Central alpha agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

–What Class are these—
Prazosin (Minipress)
Terazosin (Hytrin)
Doxazosin (Cardura)

A

Alpha-1 blockers

Alpha-Adrenergic antagonists

17
Q

–What Class are these—

Sprinolactone (Aldactone) Eplerenone (Inspra)

A

Aldosterone Antagonists (also called potassium-sparing diuretics or aldosterone receptor antagonists)

18
Q
--What Class are these---
Candesartan (Atacand)
Irbesartan (Avapro)
Losartan (Cozzar)
Valsartan **(Diovan)
Hyzaar (Losartan and hydrochlorothiazide)
A

Angiotension II
Receptor Blockers
(ARBs) or called Angiotension II receptor antagonists or inhibitors.

19
Q

–What Class are these—

Hydrochlorothiazide (HCTZ)

A

Diuretics: Thiazides

20
Q

–What Class are these—
Furosemide (Lasix)
Torsemide (Denadex)

A

Diuretics—loop

21
Q
--What Class are these---
Verapamil (Calan)
Diltiazem (Cardizem)
Amlodipine (Norvasc)
Felodipine (Plendil)
Nifedipine (Procardia, Adalat)
Nisoldipine (Sular)
A

Calcium channel blockers

22
Q
--What Class are these---
Atenolol (Tenormin)
Carvedilol (Coreg)
Labetalol (Normodyne trandate)
Metoprolol (Lopressor [Metoprolol and HCTZ]) or (Toprol)
Nadolol (Corgard)
Propranolol (Inderal)
Sotalol (Betapace)
A

Beta-blockers

23
Q
--What Class are these---
Nitrobid 
Isordil
**Isordil + hydralazine = (BiDil)
Amdur 
Ismo
*Erythrityl tetramitrate
(cardilate)
A

Nitrates

24
Q

–What Class are these—
Hydralazine (Apresoline)
Hydralazine + Isordil (BiDil) see Isordil for more information

A

Vasodilators

direct acting

25
Q
--What Class are these---
Aspirin Clopidogrel (Plavix) Ticlopidine (Ticlid)
A

Oral antiplatelet therapy

26
Q

–What Class are these—
Warfarin (Coumadin)
Prodaxa

A

Oral anticoagulation

27
Q

–What Class are these—

Pentoxifylline (Rental) Cilostazol

A

Oral antiplatelet agents for PVD

28
Q

–What Class are these—
Enoxaparin (lovenox)
Dalteparin (fragmin)

A

Low molecular Weight Heparin (LMWH)