Plasma Membrane Receptors

Question 1

Integrin terminology of GP Ia/IIa

Answer 1

a2B1

Question 2

is an integrin that binds the subendothelial collagen that becomes exposed in the damaged blood vessel wall, promoting adhesion of the platelet to the vessel wall

Answer 2

GP Ia/IIa

Question 3

bind the endothelial cell protein laminin and fibronectin, respectively

Answer 3

a5B1 and a6B1

Question 4

Further promotes platelet adhesion

Answer 4

a5B1 and a6B1

Question 5

Member of the immunoglobulin gene family

Answer 5

GP IV

Question 6

A key collagen receptor that also binds the adhesive protein thromboposdin

Answer 6

GP IV

Question 7

Is a leucine-rich repeat family CAM

Answer 7

GP Ib/IX/V

Question 8

Integrin nomenclature of GP IIb/IIIa

Answer 8

aIIb B3

Question 9

Are in a low affinity conformation as they are distributed across the plasma membrane, the SCCS, and the internal layer of the alpha granule membranes of resting platelets

Answer 9

GP IIb/IIIa

Question 10

Ligand of GP Ia/IIb

Answer 10

a2B1: Collagen
avB1: Vitronectin
a5B1: Laminin
a6B1: Fibronectin

Question 11

Ligand of GP VI

Answer 11

Collagen

Question 12

Ligand of GP Ib/IX/V

Answer 12

VWF and thrombin bind GP Iba; thrombin cleaves a site on GP V

Question 13

Ligand of GP IIb/IIIa

Answer 13

Fibrinogen, VWF