Overview of Bleeding Disorders Flashcards

1
Q

Describe the sxs of a primary hemostatic defect (clinical bleeding patterns)

A
  • prolonged initial bleed
  • bruising
  • nose bleeds
  • dental bleeding
  • menorrhagia
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2
Q

Describe the sxs of a secondary hemostatic defect (clinical bleeding patterns)

A
  • delayed bleeding
  • re-bleeding
  • joint bleeds
  • soft tissue/muscle bleeds
  • extensive bruising
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3
Q

Describe the etiology of thrombocytopenia

A
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4
Q

Describe the etiology of immune thrombocytopenic purpura (ITP)

A
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5
Q

Describe the presentation of immune thrombocytopenic purpura (ITP)

A
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6
Q

Describe the labs/diagnostic testing for immune thrombocytopenic purpura (ITP)

A
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7
Q

Describe the treatment for immune thrombocytopenic purpura (ITP)

A
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8
Q

Describe two platelet surface glycoprotein defects

A
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9
Q

Describe two platelet granule/secretion defects

A
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10
Q

What can cause acquired platelet function defects

A
  • drugs (ASA)
  • bone marrow disorders (MDS)
  • renal failure/uremia
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11
Q

Describe the etiology of von Willebrand Disease

A

PRIMARY HEMOSTATIC DISORDER

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12
Q

Describe the presentation of von willebrand disease

A
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13
Q

Describe the labs/diagnostic testing for von willebrand disease

A
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14
Q

Describe the treatment for Von Willebrand Disease

A
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15
Q

Describe the etiology of hemophilia

A
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16
Q

Describe the presentation of mild, moderate, to severe hemophilia

A
17
Q

Describe the lab testing for hemophilia

A
18
Q

Describe some causes of acquired secondary hemostatic disorders

A
  • coag factor inhibitors
  • vitamin K deficiency (gut flora, diet)
  • liver disease
19
Q

Which coag factors are vitamin K dependent

A
  • II
  • VII
  • IX
  • X

(also protein C and S)

20
Q

How do liver related primary/secondary hemostatic defects present

A
  • thrombocytopenia
  • decreased synthesis of clotting factors
  • dysfunctional fibrinogen
  • excess fibrinolysis
21
Q

Describe the agents working in hemostatic balance

A

procoagulants
- endothelium
- platelets
- clotting factors
- fibrinolytic inhibitors

VS

anti-coagulants
- protein C
- protein S
- antithrombin
- plasmin