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Naplex > Common DDI > Flashcards

Common DDI Flashcards

1
Q

Amiodarone and Warfarin

A

Amiodarone inhibits many things, including 2D6. Increased levels of warfarin. Decrease warfarin by 20-50%

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2
Q

Amiodarone and Digoxin

A

Amio inhibits P-gp, dig is a substrate, and decreases dig excretion. decrease dig dose by 50%

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3
Q

Digoxin and loop diuretics

A

Loop diuretics lower K, Mg, Ca and Na. Dig toxicity is worsened by lower Mg, K, and increased Ca. Loop diuretics may cause renal injury. Dig is really eliminated. Monitor combination

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4
Q

Valproate and Lamotrigine

A

valproate reduces lamotrigine metabolism. Increased risk of SJS. Avoid combination

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5
Q

Smoking

A

1A2 inhibition

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6
Q

Opioids

A

3A4 substrate

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7
Q

MOAi

A

Tranylcypromine, rasagiline, selegiline, linezolid, methylene blue

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8
Q

Serotonergic drugs

A

Opioids (fent, methadone, tramadol), dextromethorphan (when abused), lithium, St. Johns Wort

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9
Q

2D6 Inhibitors

A

Amiodarone, fluoxetine, paroxetine, fluvoxamine

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10
Q

2D6 substrates

A

Codine, tramadol

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11
Q

Natural Products that increase bleeding risk

A

Garlic, ginseng, ginkgo, ginger, glucosamine (5 G), vitamin E, willow bark, fish oils

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12
Q

This class of drugs increases the risk of bleeding (surprisingly)

A

SSRI and SNRIs

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13
Q

Hyperkalemia risk

A

Bactrim, CNIs, canagliflozin, drospirenone (and OCs that contain it)

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14
Q

Anti-infectives that prolong QT

A

antimalarials, azoles, macrolides, quinolones, lefamulin

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15
Q

Psych drugs that prolong QT

A

Citalopram, escitalopram, TCAs, mirtazapine, trazodone, venlafaxine, first-gen antipsychotics, ziprasidone

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16
Q

Other drugs that prolong QT

A

ondansetron, metoclopramide, promethazine,androgen deprivation therapy (leuprolide), TKIs, oxaliplatin, loperamide, tacrolimus, donepazil

17
Q

Ototoxic drugs

A

Aminoglycosides, loop diuretics, cisplatin, aspirin, vanc

Naplex (6 decks)

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