TYPE 2 DIABETES

Question 1

what is the cellular compensation that initially occurs with t2diabetes

Answer 1

hyperinsulinaemia

Question 2

after years of hyperinsulinaema what develops

Answer 2

beta cell exhaustion

Question 3

what is beta cell exhaustion

Answer 3

beta cells initally compensate by pumping out a lot of insulin btu eventually the cells run out of steam and they cant compensate anymore = lack of insulin and target cells become completely resistant to insulin

Question 4

describe the insulin level throughout the course of t2diabetes

Answer 4

initially - high levels
later - significant fall in levels

Question 5

what is it a slower onset for t2 diabetes

Answer 5

because it will be longer before a pt is assymptomatic, as they will be insulin resistant before they are diabetic

Question 6

what are the clinical features of type 2 diabetes

Answer 6

hyperglycaeia
glycosuria
diabetic neuropathy
diabetic vascular disease

Question 7

is hyperglycaemia an immune supressor

Answer 7

yes