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ACVD Exam > Immunology- Cytokines and Antigens > Flashcards

Immunology- Cytokines and Antigens Flashcards

1
Q

Erythropoietin

A

Main source: Endothelium
Classification: –
Receptor: EpoR
Target cell: Stem cells
Major function: RBC production

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2
Q

G-CSF

A

Classification: Pro-inflammatory
Main source: Fibroblasts, endothelium
Receptor: CD114
Target cell: Stem cells in BM
Major function: Granulocyte production

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3
Q

GM-CSF

A

Classification: Adaptive immunity
Main source: T cells, macrophages, fibroblasts
Receptor: CD116, CDw131
Target cell: Stem cells
Major function: Growth and differentiation of monocytes, and eosinophil, granulocytes production

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4
Q

IL-1

A

Classification: Pro-inflammatory
Main source: Macrophages, B cells, DCs
Receptor: CD121a
Target cell: B cells, NK cells, T-cells
Major function: Pyrogenic, pro-inflammatory, proliferation and differentiation, BM cell proliferation

There are two types: IL-1α and IL-1β (more active)

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5
Q

IL-2

A

Classification: Adaptive immunity
Main source: Th1 cells
Receptor: CD25
Target cell: Activated T and B cells, NK cells
Major function: Proliferation of B cells, activated T cells, NK cell function

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6
Q

IL-3

A

Classification: Adaptive immunity
Main source: T cells
Receptor: CD123, CDw131
Target cell: Stem cells
Major function: Hematopoietic precursor proliferation and differentiation

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7
Q

IL-4

A

Classification: Adaptive immunity
Main source: Th Cells
Receptor: CD124
Target cell: B cell, T cell, macrophages
Major function: Proliferation of B and cytotoxic T cells, enhances MHC class II expression, stimulates IgG and IgE production

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8
Q

IL-5

A

Classification: Adaptive immunity
Main source: Th2 Cells and mast cells
Receptor: CDw125, 131
Target cell: Eosinophils, B-cells
Major function: B-cell proliferation and maturation, stimulates IgA and IgM production

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9
Q

IL-6

A

Classification: Pro-inflammatory
Main source: Th Cells, macrophages, fibroblasts
Receptor: CD126, 130
Target cell: B-cells, plasma cells
Major function: B-cell differentiation

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10
Q

IL-7

A

Classification: Adaptive immunity
Main source: BM stromal cells, epithelial cells
Receptor: CD127
Target cell: Stem cells
Major function: B and T cell growth factor

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11
Q

IL-8

A

Classification: Pro-inflammatory
Main source: Macrophages
Receptor: IL-8R
Target cell: Neutrophils
Major function: Chemotaxis for neutrophils and T cells

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12
Q

IL-9

A

Classification: Adaptive immunity
Main source: T cells
Receptor: IL-9R, CD132
Target cell: T cells
Major function: Growth and proliferation

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13
Q

IL-10

A

Classification: Anti-inflammatory
Main source: T cells, B cells, macrophages
Receptor: CDw210
Target cell: B cells, macrophages
Major function: Inhibits cytokine production and mononuclear cell function

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14
Q

IL-11

A

Classification: Pro-inflammatory
Main source: BM stromal cells
Receptor: IL-11Ra, CD130
Target cell: B cells
Major function: Differentiation, induces acute phase proteins

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15
Q

IL-12

A

Classification: Anti-inflammatory
Main source: T cells, macrophages, monocytes
Receptor: CD212
Target cell: NK cells, macrophages, tumor cells
Major function: Activates NK cells, phagocyte cell activation, endotoxic shock, tumor cytotoxicity, cachexia

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16
Q

IL-17

A

Classification: Pro-inflammatory
Main source: Th17 cells
Receptor: IL-17R
Target cell: Monocytes, neutrophils
Major function: Recruits monocytes and neutrophils to the site of infection. Activation of IL-17 in turn activate downstream of many cytokines and chemokine, such as IL‐1, IL‐6, IL‐8, IL‐21, TNF‐β, and MCP‐1

17
Q

IL-18

A

Classification: Pro-inflammatory
Main source: Macrophages, dendritic cells, and epithelial cells
Receptor: CD218a (IL-18Ra)
Target cell: Monocytes and T cells
Major function: Recruits monocytes and T lymphocytes. Synergist with IL-12 in the induction of IFN- γ production and inhibition of angiogenesis

18
Q

IL-22

A

Classification: Anti-inflammatory
Main source: Activated T-cells and NK cells
Receptor: IL-22R
Target cell: Stromal and epithelial cells
Major function: Stimulation of cell survival, proliferation

19
Q

IL-37 (1L-1F7)

A

Classification: Anti-inflammatory
Main source: B-cells, NK cells, and monocytes
Receptor: CD218a (IL-18Ra) and potentially SIGGR
Target cell: –
Major function: Believed to act as a negative regulator inside the cell
where it interacts with SMAD3 that is activated downstream of TGFβ activity

20
Q

IL-38 (IL-1F10)

A

Classification: Anti-inflammatory
Main source: B cells and macrophages
Receptor: IL-1R1
Target cell: –
Major function: Unknown

21
Q

IFN-α

A

Classification: Pro-inflammatory
Main source: Macrophages, neutrophils, and some somatic cells
Receptor: CD118 (IFNAR1, IFNAR2)
Target cell: Various
Major function: Anti-viral

22
Q

IFN-β

A

Classification: Pro-inflammatory
Main source: Fibroblasts
Receptor: CD118 (IFNAR1, IFNAR2)
Target cell: Various
Major function: Anti-viral, anti-proliferative

23
Q

IFN-γ

A

Classification: Pro-inflammatory
Main source: T Cells and NK cells
Receptor: CDw119 (IFNG R1)
Target cell: Various
Major function: Anti-viral, macrophage activation, increases neutrophil and monocyte function, MHC-I and -II expression on cells

24
Q

M-CSF

A

Classification: Adaptive immunity
Main source: Fibroblasts, endothelium
Receptor: CD115
Target cell: Stem cells
Major function: Monocyte production and activation

25
Q

TGF-β

A

Classification: Anti-inflammatory
Main source: T cells and B cells
Receptor: TGF-βR1, 2, 3
Target cell: Activated T and B cells
Major function: Inhibits T and B cell proliferation, inhibits hematopoiesis, promote wound healing

26
Q

TNF-α

A

Classification: Pro-inflammatory
Main source: Macrophages
Receptor: CD120a,b
Target cell: Macrophages
Major function: Phagocyte cell activation, endotoxic shock, important role comprising the inflammatory response both locally and in the circulation, triggers the expression of vascular endothelial cells as well as enhances the leukocyte adhesion molecules that stimulate immune cell infiltration, crucial role in early response against viral infection by enhancing the infiltration of lymphocyte to the site of infectio

27
Q

TNF-β

A

Classification: Pro-inflammatory
Main source: T Cells
Receptor: CD120a,b
Target cell: Phagocytes, tumor cells
Major function: Chemotactic, phagocytosis, oncostatic, induces other cytokines

ACVD Exam (21 decks)

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