Glomerular Capillary Filtration Barrier

Question 1

The Glomerular Capillary Filtration Barrier prevents _______ molecules and _________ charged molecules from getting through

Answer 1

LARGE

NEGATIVELY

Question 2

Do proteins appear in urine?

Answer 2

NO

Question 3

What are 3 barriers in the GC filtration?

Answer 3

1. Fenestrations in endothelium filter based on size of molecule
2. Basement membrane is negatively charged (due to heparin sulfate) and therefore repels any negatively charged proteins that may have gotten through
3. Final barrier are podocytes (epithealial foot processes) attached to the basement membrane, along with filtration slits that lie in between - both negatively charged/

Question 4

Glomerular disease can result in __________, therefore allowing proteins to get through = _________ (protein in urine)

Answer 4

loss of the negative charge filtration barrier

Proteinuria