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BRS Y2 > obesity > Flashcards

obesity Flashcards

1
Q

obesity definiton

A

excessive fat in adipose tissue, that impairs health

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2
Q

what drives obesity

A

ability to play outside
car use
screen time
education level
educational achievement
poverty
social deprivation
interaction of environmental and genetic variance in multifactorial disease

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3
Q

obesity is associated with what comorbidities

A

diabetes
CVD- stroke/MI
cancer
OPA
depression

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4
Q

obesity treatment pathway

A
  1. determine degree of overweight/obestiy
  2. lifestyle, comorbidities, willingness to change
    2a: referral to specialist care
    or
    2b: management- lifestyle change/drug treatment
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5
Q

issues with leptin deficiency (or resistance)

A

infertility
stunted linear growth
hyperphagia
decreased:
1.body temp
2.energy expenditure
3.immune function

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6
Q

normal physiological function of leptin

A

regulate appetite -anti-starvation hormone
control metabolism

regulate bone bass
regulate menstrual cycle
increase heart rate

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7
Q

what happens when you administer leptin in leptin deficient children

A

reduce appetite an body weight

restores LH pulsatility- restore FSH/LH after 12 months//and for women with amenorrhea

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8
Q

treatment for obesity-drugs

A

orlistat -gastric+pancreatic lipase inhibitor
reduce dietary fat absorption by 30%

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9
Q

effects of GLP-1

A

reduce BP/plasma glucose and plasma lipid

reduce appetite and increases satiety

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10
Q

what is liraglutide
how to administer, dosing on T2DM
effects?

A

long acting GLP-1 receptor agonist

daily injections
double dose for T2DM
4-5%weight loss

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11
Q

what is semaglutide

A

long-acting GLP-1 receptor agonist

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12
Q

tirzepatide

A

long acting GLP-1 receptor AND GIP receptor coagonist

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13
Q

what does GIP stand for

A

gastric inhibitory polypeptide

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14
Q

what is cagrilintide

A

long acting amylin analogue

given with semaglutide

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15
Q

what is retatrutide

A

triple agonist of GIP, GLP-1 and glucagon receptors

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16
Q

bariatric surgery-Consider for patients with (BMI)

A

BMI of 40 kg/m2 or more
BMI of 35-40 kg/m2 and other co-morbidities
BMI of 30-34.9 kg/m2 for newly diagnosed T2DM.

a first-line option for adults with a BMI >50 kg/m2.

17
Q

bariatric surgery-Consider for patients with (FACTORS)

A

– non-surgical measures CAUSE NO weight loss for at least 6 months
– (will be) receiving receive intensive specialist management
– fit for anaesthesia and surgery
– commit to the need for long-term follow-up.

18
Q

types of bariatric surgery

A

gastric bypass-top of stomach connected to small intestine.

gastric band

sleeve gastrectomy -removed portion of stomach

19
Q

what is
long acting amylin analogue

given with semaglutide

A

cagrilintide

BRS Y2 (60 decks)

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