L71 Barker- Pathophys of pain

Question 1

chronic pain means it has lasted at least how long

Answer 1

3 months

Question 2

4 temporal features of pain

Answer 2

onset, duration, course, pattern

Question 3

T or F: pain is an emotion that impacts mood

Answer 3

true

Question 4

Temperature sensitive channel involved in pain signaling

Answer 4

transient receptor potential cation channel (TRP)

Question 5

Heat sensitive
A. TRPV (vanniloid)
B. TRPM (Melastatin)

Answer 5

A

Question 6

Cold sensitive
A. TRPV (Vanniloid)
B. TRPM (Melastatin)

Answer 6

B

Question 7

Acid sensitive channel involved in pain signaling

Answer 7

Acid sensing ion channel (ASIC)

Question 8

What is the acid sensing ion channel (ASIC) activated by? What happens after?

Answer 8

H+, conducts Na+ -> feel pain

Question 9

2 compunds listed under chemical irritant sensitive channel involved in pain signaling

Answer 9

histamine
bradykinin

Question 10

what are the three different pain fibers that transduce different pain signals?

Answer 10

Abeta-fibers
Adelta-fibers
C-fibers

Question 11

Non-noxious (touch, pressure)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 11

A

Question 12

Innervate the skin
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 12

A

Question 13

“faster” (35-75 m/s)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 13

A

Question 14

Pain, cold
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 14

B

Question 15

Myelinated
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 15

B

Question 16

“fast” 2-35 m/s
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 16

B

Question 17

“first pain” reflex arc. Sharp/prickly
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 17

B

Question 18

Pain, temp, touch, pressure, itch (polymodal)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 18

C

Question 19

Unmyelinated
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 19

C

Question 20

Slow (0.5-2 m/s)
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 20

C

Question 21

“second pain” Dull/aching
A. Aβ-fibers
B. Aδ-fibers
C. C-fibers

Answer 21

C

Question 22

what plays an important role in heightening pain responding? (weird wording barker)

Answer 22

Substance P*

Question 23

Substance P: ****
-(Vasodilation or Vasoconstriction)
- Degranulation of _____ cells
- Release of ______
- ________ and prostagandins

Answer 23

Vasodilation
mast
histamine
inflammation

Question 24

T or F: Substance P increases expression of pain receptors (sensitization)

Answer 24

tru

Question 25

Neuropathic pain sensitization:
When substance P binds NK1, what effect does it have on AMPA and NMDA?

Answer 25

increased expression and sensitivity of both

Question 26

PLC -> PKC in what type of pain sensitization

Answer 26

neuropathic

Question 27

T or F: There is a low expression of opioid receptors in the brain stem along the descending pathway

Answer 27

False, high expression

Question 28

what is the important receptor to think of when thinking of opioids and the brain

Answer 28

mu