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Pharmacy Outcomes Exam 3 > Health Related Quality of Life > Flashcards

Health Related Quality of Life Flashcards

1
Q

Quality of Life

Community, Education, Housing, Family Life, Friendships, Marriage, Nation, Health, Self, Standard of living, Work, Self, Neighborhood

A
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2
Q

_________is a measureable healthcare outcome

A

Health-related Quality of Life (HRQoL)

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3
Q

Health related quality of life can be used to evaluate:

drugs in ___________
provider ________
the progress of pts receiving drug therapy

A

clinical trials

performance

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4
Q

Health related quality of life is useful when

Drug therapy is ______________vscurative
Drug is effective but also toxic
Drug is used __________to prevent complication of asymptomatic disease
Several drugs are available w/ differing _________ profiles

A

palliative

long term

adverse effects

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5
Q

Health related Quality of Life

Multidimensional construct

Depending on measurement

a single outcome score (________approach)

an array of score quality of life dimensions (_________approach)

A

utility

psychometric

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6
Q

How to measure HRQoL?

Standardized questionnaries=

Instruments
Tools
___________
Scales
Measures

A

Surveys

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7
Q

HEALTH STATUS ASSESSMENT
General Health Status Instruments
Domains:
Physical
Mental
___________
General Health

A

Social/role

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8
Q

Generic Instruments
Allow _________________
Applicable to ___________conditions
-Reliability/validity

Examples
Medical outcomes study 36-item short form health survey (MOS SF36)

Sickness Impact Profile

EQ-5D

A

comparisons

multiple

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9
Q

SF-36
Consists of 8 health domains:
Physical functioning (10 items)
Bodily Pain (2 items)
Role limitations due to physical health issues (4 items)

Role limitations due to personal or emotional
health issues (4 items)

Emotional well-being (5 items)

Social functioning(2 items)

Energy/fatigue (4 items)

General health perceptions (5 items)

A
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10
Q

SF-36
Each domain score ranges from 0 to 100 with higher score defining __________health state

A

better

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11
Q

SF-36 EXAMPLE
Domain=Vitality/Energy/fatigue
Answer choices: 1) All of the time; 2) Most of the time; 3) A good bit of the time; 4) Some of the time; 5) A little of the time; 5) None of the time

Questions- How much of the time during last four
weeks

Did you feel full of pep?
Did you have a lot of energy?
Did you feel worn out?
Did you feel tired?

A
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12
Q

SF-36 EXAMPLE
Domain=Role-emotional
Answer choices:
1) Yes or 2) No

Questions- During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of emotional problems (such as feeling depressed or anxious)?

Cut down on the amount of time you spent on work or other activities

Accomplished less than you would like.

Did work or other activities less carefully than usual.

A
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13
Q

ASTHMA QOL

Domain- Activities
How limited have you been during the last 2 weeks in these
activities as a result of your asthma:

Q1: Strenuous activities (such as hurrying, exercising, running
upstairs, sports)

Q3: Social activities (such as playing with pets/children, visiting
friends/relatives)

1) Totally limited
2) Extremely limited
3) Very limited
4) Moderate limitation
5) Some limitation
6) A little limitation
7) Not limited at all

A
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14
Q

ASTHMA QOL

Domain- Symptoms

Q6: How much discomfort or distress have you felt over the last 2 weeks as a result of chest tightness?

Response choices
1) A very great deal
2) A great deal
3) A good deal
4) Moderate amount
5) Some
6) Very little
7) None

A
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15
Q

WHICH INSTRUMENT TO USE: GENERIC OR
DISEASE-SPECIFIC ?

Combination is usually recommended

Start with a __________ and append/modify with
disease-specific instrument

A

generic

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16
Q

_______________
Consistency
An instrument must be reliable in order to be
valid

Aspects of reliability:
Stability
Internal consistency
Equivalence (inter-rater reliability)

A

reliability

17
Q

Aspects of reliability
___________
Internal consistency
Equivalence (inter-rater reliability)

A

Stability

18
Q

_________:extent to which the same results are
obtained on repeated administration (test-retest
correlation)

A

Stability

19
Q

____________:Do subparts measure the same domain? (Cronbach alpha)

A

Internal consistency

20
Q

___________– Do two people given the same
rules of measurement record the same results?

A

Equivalence

21
Q

________________

The degree to which an instrument measures the
construct it is supposed to measure

Even if instrument is reliable, it may not be valid

A

Validity

22
Q

Types of Validity
Content validity
Criterion validity
Construct validity

A
23
Q

Is the content of the measure representative of all aspects of the construct?

A

Content validity

24
Q

__________– Is it useful as a predictor?

A

Criterion validity

25
Q

_________(abstract) How does this instrument compare to other ways of measuring the same construct?

A

Construct validity

26
Q

ISSUES IN MEASURING HRQOL

_____________

Acceptance

________ of the questions or domains

Patient vs caregiver vs healthcare professional

_________and complexity

A

responsiveness

weighting

Length

27
Q

UTILITIES VS HEALTH STATUS MEASURES

Utilities
positive: reflect preferences for ________

positive: allow morbidity and mortality to be combined in a single weighted measure (i.e. QALY)

negative: cognitively complex, not as sensitive to __________clinical changes

A

health

small

28
Q

UTILITIES VS HEALTH STATUS MEASURES
Health Status (SF-36, AIMS):
+used to differentiate between patients with
_____________
+used to predict ___________ outcomes
+used to measure a change in health status _______________
- May not incorporate mortality, duration of
survival, or patient preference

A

different diseases

future

over time

29
Q

UTILITIES VS HEALTH STATUS MEASURES

No clear superiority

Not interchangeable (poor to moderate
correlations)

Current research on using Health Status scores
(e.g., EQ-5D) to estimate QALYs

A
30
Q

Examples of outcomes most important to pts

__________(e.g. mortality; years of life lost;5-years survival

__________(e.g. stroke, cardiac arrest, disease recurrence)

__________(e.g. symptoms;functions; feelings)

A

Survival

Morbid events

Patient-reported

31
Q

____________:an umbrella term to describe a broad spectrum of disease and treatment outcomes reported subjectively by the patient

A

Patient Reported Outcome

31
Q

PATIENT-REPORTED OUTCOMES

Some HRQoL instruments can be used to measure patient-reported outcomes

But not interchangeable:
-some PROs too ___________(one domain)

-some HRQoL instruments – too broad (not sensitive enough to _________changes)

A

narrows

clinical

32
Q

_________________

Defined as ‘the measurement of any aspect of a
patient’s health status that comes directly from
the patient’

Individual symptoms (e.g. pain)

Overall impact of disease (e.g. asthma)

Feelings about disease (e.g. worry )

A

PATIENT-REPORTED OUTCOMES (PROS)

33
Q

Sleep Disturbance Adult

PROMIS Item Bank v1.0 – Sleep Disturbance – Short Form 8a

In the past 7 days…
My sleep was refreshing
Not at all
A little bit
Somewhat
Somewhat
Very much

My sleep was restless
Not at all
A little bit
Somewhat
Somewhat
Very much

I worried about not being able to fall asleep
Not at all
A little bit
Somewhat
Somewhat
Very much

A
34
Q

Pain Interference
Adult

PROMIS Item Bank v1.0– Pain Interference– Short Form 8a

In the past 7 days…

How much did pain interfere with your day to day activities?
Not at all
A little bit
Somewhat
Quite a bit
Very much

How much did pain interfere with your enjoyment of life?
Not at all
A little bit
Somewhat
Quite a bit
Very much

How much did pain interfere with your household chores?
Not at all
A little bit
Somewhat
Quite a bit

A
35
Q

All of the following are generic HRQOL instruments except:

A. SF 36
B.EQ5D
C.Arthritis Impact Scale
D.Sickness impact scale

A
36
Q

Which HROL domain is not captured in SF36 measure?

A.Vitality
B.Sexual Health
C.Role-Emotional
D.Physical Health

A
37
Q

Validity address the degree to which an instrument measurements the construct it is supposed to measure

TRUE!

A
38
Q

Relliability address whether an instrument can be used as a predictor of future outcomes

FALSE!

A

Pharmacy Outcomes Exam 3 (7 decks)

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