Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Phase 4 > Anaesthetics > Flashcards

Anaesthetics Flashcards

1
Q

why are patients fasted before general anaesthesia?

A

to reduce risk of aspiration of stomach contents and subsequent pneumonitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

when is risk of aspiration highest in general anaethesia?

A

before and during intubation and during extubation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is the typical fasting for an operation?

A

6 hours before no food or feeds
2 hours before no clear fluids - fully NBM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is preoxygenation in anaesthesia?

A

when patient has several minutes of breathing 100% O2 to give a reserve of oxygen for the period between when they lose consciousness and when they are successfully intubated and ventilated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is premedication in general anaesthesia?

A

medication given to a patient before they are put under inorder to relax them, reduce anxiety, pain and make intubation easier

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what 3 medications may be used for premedication?

A

benzodiazepines - to relax muscles and reduce anxiety as well as causing amnesia - midazolam
opiates - to reduce pain and hypertensive response to laryngoscope - fentanyl or alfentanyl
Alpha-2adrenergic agonists - help with sedation and pain - clonidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

when is rapid sequence induction used?

A

in emergency/non-fasted patients
in high risk patients - GORD, pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is induction in anaesthetics?

A

when the patient becomes unconsious

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are 2 methods that can be used in rapid sequence induction to reduce risk of aspiration?

A

upright positioning of patient
cricoid pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the triad of general anaesthesia?

A

Hypnosis
muscle relaxation
analgesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the 2 delivery methods of hypnotic agents?

A

IV or inhalation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what are 4 IV medications used as hypnotic agents in general anaesthesia?

A

propofol - most common
ketamine
thiopental sodium
etomidate - rare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are 4 Inhaled hypnotic agents used in general anaesthesia?

A

sevoflurane - most common
desflurane - bad for environment
isoflurane - rare
nitrous oxide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is total IV anaesthesia, what medication is usually used and what are the benefits?

A

when IV medication is used for both induction and maintenance of general anaesthesia

propofol most commonly used

nicer recovery for patient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do muscle relaxants work?

A

block acetylecholine at neuromuscular junction from stimulating response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the two categories of muscle relaxants?

A

depolarising and non-depolarising

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what medications can reverse the effect of neuromuscular blocking agents in anaesthetics?

A

cholinesterase inhibitors - neostigimine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is an example of a depolarising muscle relaxant?

A

suzamethonium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what are 2 examples of non-depolarising muscle relaxants?

A

rocuronium
atracurium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what medication can be used to reverse non depolarising muscle relaxants specifically?

A

sugammadex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what are 4 common medications used for analgesia in general anaesthetics?

A

fentanyl
alfentanil
remifentanil
morphine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what 3 antiemetics are often given for postoperative nausea?

A

ondansetron (5HT3 receptor antagonist) - Avoid in long QT risk
Dexamethasone - caution in diabetes or immunocompromise
cyclizine - H1 receptor antagonist - caution in HF and elderly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what tests can be done to check muscle relaxants have worn off before emergence?

A

nerve stimulation either of ulnar nerve for thumb twitching or of facial nerve for orbiculares oculi muscle movement

normally tested in train of four - stimulate nerve 4x > shouldn’t get weaker with repeated stimulation > sign muscle relaxant not quite worn off yet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what are 2 most common risks of general anaesthesia?

A

sore throat
post op nausea and vomiting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

what are 7 significant risks of general anaesthesia?

A

accidental awareness
aspiration
dental injury
anaphylaxis
cardiovascular event
malignant hyperthermia - rare
death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

what is malignant hyperthermia?

A

rare potential fatal response to anaesthesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

what medications increase risk of malignant hyperthermia?

A

volatile anaesthetics
suxamethonium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

what is the inheritance pattern for increased risk of malignant hyperthermia?

A

autosomal dominant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

what are 6 signs of malignant hyperthermia?

A

Hyperthermia
increased CO2 production
tachycardia
muscle rigidity
acidosis
hyperkalaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

what is the treatment of malignant hyperthermia?

A

Dantrolene - interrupts muscle rigidity and hypermetabolism by interfering with movement of calcium ions in skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

what dose of dantrolene is given in malignant hyperthermia?

A

2-3mg/Kg then a further 1mg/kg if necessary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

How are peripheral nerve blocks usually performed?

A

by ultrasound with help of nerve stimulator to accurately apply anaesthesia to target nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

what is central neuraxial anaesthesia also known as?

A

spinal block

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

where is anaesthsia injected in a spinal block?

A

local anaesthetic into CSF within subarachnoid space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

where is a spinal block usually placed?

A

L3/4 or L4/5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

how long do spinal blocks usually last?

A

1-3 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

where is the anaesthesia injected in an epidral?

A

outside dural mata in epidural space - medication diffuses to surrounding tissues and spinal nerve roots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

what medication is often used in epidurals?

A

levobupivacaine w/ or w/o fentanyl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

what are 6 adverse effects of epidural?

A

headache if dura is punctured
hypotension
motor weakness in legs
nerve. damage
infection including meningitis
haematoma - may cause spinal cord compression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

what are 2 added risks to epidural in pregnancy?

A

prolonged second stage
increased probability of instrumental delivery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

what size endotrachial tubes are generally for women?

A

7-7.5mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

what side endoctrachial tubes are generally for men?

A

8-8.5mm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

what is the name of the additional hole in the tip of the endotrachial tube in case of blockages to the main hole?

A

murphy’s eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

what can be used to check the pressure of the endotrachial pilot balloon?

A

a manometer (pressure sensor) to check for under or over inflation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

what are two devices that can be used to help with endotrachial intubation?

A

A bougie - smaller than endotrachial tube, inserted into trachea first to guide endotrachial tube

Stylet - metale wire inserted into endotrachial tube to bend to correct shape

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

what is awake fibre optic intubation?

A

endoscopy guided intubation in awake patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

what is trismus?

A

difficulty opening the jaw due to pain or restriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

what are supraglottic airway devices?

A

1st line after failure of intubation
form a seal around the opening of the larynx
can have inflatable or non-inflatable cuffs

I-gel = non-inflatable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

what are guedel airways?

A

oropharyngeal airway that is ridgid and creates a passage between front of teeth and base of tongue maintaining a patent upper airway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

how do you measure the size of a guedel airway?

A

from centre of mouth to angle of jaw

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

how are nasopharyngeal airways sized?

A

from edge of nostril to tragus of ear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

what is a contraindication to nasopharyngeal airway insertion?

A

base of skull fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

what are 6 signs of base of skull fracture?

A

Racoon eyes
battles sign - bruising of mastoid process
CSF rhinorrhoea
cranial nerve palsy
haemotympanum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

what are 5 indications for tracheostomy?

A

resp failure with need for long term ventilation
prolonged weaning from mechanical ventilation in ICU
upper airway obstruction
management of resp secretions in patients with paralysis
reducing risk of aspiration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

what are the 4 levels of airways for patients?

A

plan A - laryngoscopy and tracheal intubation
plan B - supraglottic airway device
plan C - face mask ventilation and wake patient
plan D - cricothyroidotomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

what are arterial lines?

A

type of cannula in artery which can measure BP and take ABG samples

NEVER GIVE MEDICATION THROUGH ARTERIAL LINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

what are 3 veins that central lines can be inserted into?

A

internal jugular
subclavian
femoral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

what are vas caths?

A

type of central venous catheter inserted temporarily usually into internal jugular or femoral vein with 2/3 lumens that can be used for short term haemodialysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

what is a picc line?

A

a type of central line fed through venous system peripherally until in vena cava or R atrium

low risk of infection and can stay for longer periods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

what is a hickman line?

A

a type of tunnelled central venous catheter which entres skin on chest and travels through subcut tissue into subclavian or jugular vein to sit in superior vena cava

used for regular IV treatment e.g. chemo or dialysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

what is a swan-ganz catheter?

A

a pulmonary artery catheter that’s inserted into internal jugular vein though central venous system through heart and into pulmonary artery

can be used to measure pressures in pulmonary artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

what is a portacath?

A

type of central venous catheter with small chamber under skin at top of chest used to access device that is connected to catheter that travels through SC tissue into subclavian vein with tip in SVC or R atrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

what are 3 scoring systems that can be used to predict mortality at time of admission to ICU?

A

APACHE - acute physiology and chronic health evaluation

SAPS - simplified acute physiology score

MPM - mortality prediction model

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

what does PEG stand for?

A

percutaneous endoscopic gastrostomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

how should TPN be delivered?

A

through central line to avoid thrombophlebitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

what are 9 complications of ICU admission?

A

Ventilator associated lung injury
ventilator associated pneumonia
catheter related blood stream infections
catheter associated UTIs
stress related mucosal disease - erosion of upper GI tract
Delirium
VTE
critical illness myopathy
critical illness neuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

what are 2 short term complications of ventilators?

A

pulmonary oedema
hypoxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

what are 3 traumas caused by ventilators?

A

barotrauma - damage from pressure changes
volutrauma - damage from overinflation of alveoli
inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

what are 4 long term complications of ventilator trauma?

A

lung fibrosis
reduced lung function
recurrent infection
cor-pulmonale

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

what patient positioning reduces risk of ventilator associated pneumonia?

A

bed at 30 degree angle with head elevated - reduces bacterial aspiration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

what is stress related mucosal disease?

A

damage to stomach mucosa due to impaired blood flow. increases risk of upper GI bleed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
72
Q

what can be done to reduce risk of stress related mucosal disease?

A

PPIs or H2 receptor antagonists

starting NGs early even in small volumes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
73
Q

what medication can be used in ICU to sedate patients?

A

Dexmedetomidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
74
Q

what are 2 options for reducing risk of VTE in ICU?

A

LMWH
Intermittened penumatic compression - flowtrons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
75
Q

what is critical illness myopathy?

A

muscle wasting and weakness during critical illness
affects limbs and respiratory muscles most
Corticosteroids and muscle relaxants increase risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
76
Q

what are 2 long term effects of critical illness myopathy?

A

reduced exercise capacity
reduced QOL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
77
Q

What is critical illness polyneuropathy?

A

degeneration of sensory and motor nerve acons during critical illness and ICU treatment often alongside critical illness myopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
78
Q

what can reduce risk of critical illness polyneuropathy?

A

good glycaemic control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
79
Q

what is the pattern of critical illness polyneuropathy?

A

symmetrical weakness, decreased muscle tone and reduced reflexes

80
Q

what is acute respiratory distress syndrome?

A

severe inflammatory reaction of lungs causing atelectasis, pulmonary oedema, decreased lung compliance and fibrosis (after 10 days)

clinically causes acute resp distress, hypoxia, bilateral infliltrates on CXR

81
Q

what is the management of ARDS?

A

resp support
prone positioning
careful fluid management to avoid excess collecting in lungs

82
Q

why are patients with ARDS positioned prone?

A

reducing compression of lungs by other organs
improve blood flow to lungs
improve clearing of secretions
improve overall oxygenation
reduce need for mechanical ventilation

83
Q

what % FiO2 can be delivered via nasal cannulae?

A

24-55% O2

84
Q

what % FiO2 can a simple face mask deliver?

A

40-60% O2

85
Q

what FiO2 can venturi masks deliver?

A

24-60% O2

86
Q

what FiO2 can non-rebreathe mask deliver?

A

60-95% O2

87
Q

what is the FiO2 of 1L nasal cannula?

A

24%

88
Q

what is the FiO2 of 2L nasal cannula?

A

28%

89
Q

what is the FiO2 of 4L nasal cannula?

A

36%

90
Q

what is the FiO2 of 5L via face mask?

A

40%

91
Q

what is the FiO2 of 8L via face mask?

A

60%

92
Q

what is the FiO2 of 8L via non-rebreathe mask?

A

80%

93
Q

what is the FiO2 of 10L via non-rebreathe mask?

A

95%

94
Q

what is positive end expiratory pressure (PEEP)?

A

additional pressure in the airway at the end of expiration to help keep the airways from collapsing and improve ventilation of alveoli

95
Q

what is CPAP?

A

continuous positive airway pressure - constant pressure added to lungs to keep airway expanded (PEEP) used in conditions where airways are likely to collapse

96
Q

what is NIV?

A

a full face mask, hood or tight fitting nasal mask that forcefully blows air into the lungs to ventilate them

BiPAP - Bilevel positive ailrway pressure

cycles of high and low pressure to correspond to inspiration and expiration

97
Q

what are 7 basic controls for mechanical ventilation?

A

FiO2
Resp rate
tidal volume
inspiratory:expiratory ratio
peak flow rate
peak inspiratory pressure
positive end expiratory pressure

98
Q

what is preload in cardiophysiology?

A

the amount the heart muscle is stretched when filled with blood BEFORE contraction

relates to the volume of blood in the ventricle at the end of diastole

99
Q

what is afterload in cardiophysiology?

A

the resistance that the heart muscle has to overcome to eject blood from the left ventricle

How much resistance there is to pushing blood through aortic valve

100
Q

what are 2 common causes of raised afterload?

A

HTN
aortic stensis

101
Q

what is contractility in cardiophysiology?

A

the strength of the heart muscle contraction

102
Q

what is systemic vascular resistance in cardiophysiology?

A

resistance in systemic circulation that the heart must overcome to pump blood around the body

103
Q

what is the stroke volume in cardiophysiology?

A

volume of blood ejected in each beat

104
Q

what is the cardiac output in cardiophysiology?

A

the volume of blood ejected by the heart per minute

105
Q

what is the equation for cardiac output?

A

CO = Strove volume x heart rate

106
Q

what is mean arterial pressure in cardiophysiology?

A

the average blood pressure of the entire cardiac cycle including both systole and diastole

A product of cardiac output and systemic vascular resistance

107
Q

what are 5 complications of low mean arterial pressure?

A

hypoperfussion
hypoxia
anaerobic respiration
lactate production
tissue damage

108
Q

How is central venous pressure monitored?

A

through a central venous catheter in vena cava/R atrium

109
Q

what do positive inotropes do?

A

increase contractility fo the heart increasing cardiac output and MAP

used for patients with low cardiac output e.g. HF, MI or following heart surgery

110
Q

how do most positive inotropes work?

A

catecholamines which stimulate the sympathetic nervous system via alpha and beta adrenergic receptors

111
Q

what are 5 examples of catechloamine positive inotropes?

A

adrenaline
dobutamine
isoprenaline

noradrenaline - weak inotrope, mostly vasopressors
dopamine - at higher infusion rates

112
Q

what are 2 examples of non-catechloamine positive inotropes?

A

milrinone - phosphdoesterase-3 inhibitor

levosimedan - increases myocyte sensitivity to calcium

113
Q

how are positive inotropes given?

A

through central venous catheter

114
Q

what are 3 examples of negative inotropes?

A

beta blockers
calcium channel blockers
flecainide

115
Q

how do vasopressors work?

A

cause vasoconstriction which increased systemic vascular resistance therefore increasing mean arterial pressure

116
Q

what are 6 examples of vasopressors?

A

noradrenalin - central line
vasopressin - central line
adrenaline - central line or bolus
metaraminol - bolus/infussion
ephederine - bolus
phenylephrine - bolus/infusion

117
Q

what are 2 examples of antimuscarinics used to treat bradycardia?

A

glycopyronium - block acetylchline recepros

Atropine

118
Q

what is an intra-aortic balloon pump?

A

a ballon inserted through the femoral artery to the descending aortic artery which is inflatted and deflated synchronised to the heart contractions to push blood back into the coronary arteries in diastole by inflating and pull blood out the heart by deflating in systole

causing increased coronary blood flow, reduces afterload and increased cardiac output

119
Q

what are 5 indications for acute dialysis?

A

AEIOU

Acidosis - severe and non-responsive
Electrolyte abnormalities - treatment resistant
Intoxication - severe overdose
Oedema - severe and unresponsive pulmonary oedema
Uraemia symptoms - seizure, reduced conciousness

120
Q

what are 2 different types of haemodialysis?

A

continuous renal replacement therapy
intermittent haemodialysis

121
Q

what are 2 positional manoeuvres that can be used to open airway?

A

head tilt/chin lift
jaw thrust - preferred if ?C spine injury

122
Q

what are oropharyngeal (guedel) airways used?

A

for very short procedures
to bridge difficult airways

123
Q

when are laryngeal masks used (igel)?

A

when paralysis not required and patient able to self ventilate

not suitable for high pressure ventilation
poor control against reflux

124
Q

when are tracheostomies used?

A

reduces work of breathing an dead space
useful for slow wean
humidified air required
useful in ITU

125
Q

when are endotracheal tubes used?

A

provides optimal control of airway
short and long term
paralysis required
higher ventilation pressures

errors in insertion may lead to oesophageal intubation - need to monitor end tidal CO2 (capnography)

126
Q

what is the american society of anaesthesiologists (ASA) level 1 classification of patients?

A

normal healthy, non- smoker, minimal alcohol

127
Q

what is the american society of anaesthesiologists (ASA) level 2 classification of patients?

A

mild systemic disease - current smoker, social drinker, pregnant, obese, well controlled diabetes/HTN, mild lung disease

128
Q

what is the american society of anaesthesiologists (ASA) level 3 classification of patients?

A

Patient with severe systemic disease

Functional limitation, poor control HTN/DM, morbid obesity, COPD, hepatitis, alcohol dependance, pacemaker, reduced ejection fraction, end stage renal disease with dialysis, MI >3 months ago, cerebrovascular accidnet

129
Q

what is the american society of anaesthesiologists (ASA) level 4 classification of patients?

A

Patient with severe systemic disease that is constant threat to life

MI <3 months ago, ongoing cardiac ischaemia/severe valve dysfunction, severe reduction in ejection fraction, sepsis, DIC, ARD, end stage renal no dialysis

130
Q

what is the american society of anaesthesiologists (ASA) level 5 classification of patients?

A

Moribund patient not expected to survive without operation

ruptures AAA, massive trauma, intracranial bleed with mass effect, ishcaemic bowel with cardiac pathology/multiple organ failure

131
Q

what is the american society of anaesthesiologists (ASA) level 5 classification of patients?

A

declared brain dead who’s organs are being harvested

132
Q

what is the MOA of propofol?

A

GABA receptor agonist

133
Q

what is a common side effect of propofol?

A

pain on IV injection

134
Q

what are 3 advantages of propofol?

A

rapid onset of anaesthesia

rapidly metabolised and little accumulation of metabolites

antiemetic properties

135
Q

what 2 disadvantage of propofol?

A

causes moderate myocardial depression - hypotension
Pain on injection

136
Q

what general anaesthetic has a very rapid onset but can cause marked myocardial depression and build up of metabolites?

A

sodium thiopentone - good for rapid sequence induction though cannot be used for maintenance infusion

137
Q

what is the MOA of ketamine?

A

NMDA receptor antagonist

138
Q

what are 2 advantages of ketamine as general anaesthesia?

A

moderate to strong analgesia also
little myocardial depression - good in haemodynamic instability

139
Q

what is 1 side effect of ketamine as anaesthetic?

A

may induce state of dissociate anaesthesia and nightmares

140
Q

what are 3 disadvantages of etomidate?

A

no analgesic properties

unsuitable for maintainance as may result in adrenal supression

post operative vomiting is common

Myoclonus is an adverse effect

141
Q

what is an adverse effect of thiopental?

A

laryngospasm

142
Q

what are 3 examples of volatile anaesthetics?

A

isoflurane
desflurane
sevoflurane

143
Q

what are 3 adverse effects of volatile anaesthetics?

A

myocardial depression
malignant hyperthermia

halothane is hepatotoxic

144
Q

when should NOS not be used for anaesthesia?

A

can diffuse into gas filled body compartments so should in avoided in pneumothorax as can cause tension

145
Q

what is the largest cannula?

A

Orange - 16g - 270ml/min

146
Q

what is the smallest canula?

A

blue - 22g - 33ml/min

147
Q

what is the gage and flow rate of a grey canula?

A

16g
180ml/min

148
Q

what is the gage and flow rate of a green cannula?

A

18g
80ml/min

149
Q

what is the gage and flow rate of a pink cannula?

A

20g
54ml/min

150
Q

what are 5 muscle relaxants?

A

suxamethonium
atracurium
vecuronium
pancuronium
rocuronium

151
Q

what is the only depolarising muscle relaxant?

A

suxamethonium

152
Q

what is the MOA of suxamethonium?

A

inhibits action of acetylcholine and NM junction

153
Q

which muscle relaxant causes fasciculation prior to muscle relaxation?

A

suxamethonium

154
Q

what muscle relaxant has the shortest onset and duration?

A

suxamethonium

155
Q

what are 3 adverse effects of suxamethonium?

A

hyperkalaemia

malignant hyperthermia

genetic variation causing lack of acetylcholinesterase to break it down => longer to wear off

156
Q

what is the duration of action of atracurium?

A

30-45 mins

157
Q

what can be used to reverse atracurium?

A

neostigimine - acetylcholinesterase inhibitor

158
Q

what is an advantage of atracurium?

A

not renally or hepatically excreted - broken down by hydrolysis in tissues

159
Q

what are 3 side effects of atracurium?

A

generalised histamine release causes

facial flushing
tachycardia
hypotension

160
Q

what is the duration of action of vecuronium?

A

30-40 mins

161
Q

how is vecuronium excreted?

A

broken down by liver and kidneys => effect is prolonged in organ dysfunction

162
Q

neostigimine can reverse what 2 muscle relaxants?

A

atracurium and vecuronium

163
Q

what is the onset of action for pancuronium?

A

2-3 minutes

164
Q

what is the duration of action of pancuronium?

A

up to 2 hours

165
Q

is pancuronium reversible with neostigimine?

A

partially reversible

166
Q

what is a contraindication to suxamethonium?

A

penetrating eye injuries or acute narrow angle glaucoma as increase intra-ocular pressure

167
Q

what are 5 early (<5 days) causes of post operative pyrexia?

A

blood transfusion
cellulitis
UTI
Pulmonary atalectasis - unlikely

Physiological systemic inflammatory reaction - usually in 1st day

168
Q

what are 5 late (>5 days) causes of post op pyrexia?

A

VTE
Penumonia
Wound infection
anastomotic leak

169
Q

what is postoperative ileus?

A

AKA parylitic ileus is a common complication of bowel surgery causing reduced bowel peristalsis and pseudo obstruction

170
Q

what are 5 features of postoperative ileus?

A

abdo distension/bloating
abdo pain
nausea/vom
inability to fart
inability to eat

171
Q

what can contribute to postoperative ileus?

A

deranged electrolytes - potassium, magnesium and phosphate

172
Q

what is the management of postoperative ileus?

A

NBM
NG tube if vomiting
IV fluids + electrolytes if needed
TPN

173
Q

what are the 3 ‘time out’ times in the operating theatre?

A

before induction of anaesthesia

before incision

before patient leaves

174
Q

what must be checked before induction of anaesthesia?

A

patient confirmed site, identity, procedure, consent

site is marked
anaesthesia safety check
Pulse ox on patient and working
Allergies
difficult airway or aspiration risk
risk of >500ml blood loss

175
Q

what is the antidote to local anaesthetic toxicity?

A

intralipid (lipid emulsion) 20%

1.5ml/Kg over 1 min followed by 0.25ml/kg/min infusion

176
Q

what are 5 local anaesthetic agents?

A

Lidocaine
Bupivacaine
levobupivacaine
Tetracaine
Cocaine

177
Q

what is the MOA of local anaesthetics?

A

inhibit neuronal condition by preventing opening of voltage gated sodium channels on axon preventing depolarisation of the axon and therefore stopping the action potential

178
Q

what are 3 medications that interact with lidocaine?

A

beta blockers
ciprofloxacin
phenytoin

179
Q

what are the signs of local anaesthetic toxicity?

A

initially CNS overactivity - sensory sensations, seizure, headache - then CNS depression - coma

then cardiac arrhythmias and arrest

180
Q

what medication can be added to local anaesthetics to allow for increased doses by reducing systemic absorption?

A

adrenaline - causes vasoconstriction so less systemic absorption

181
Q

what are 3 characteristics of lidocaine?

A

hepatically metabolised
protein bound
renally excreted

182
Q

what surgeries may use cocaine as local anaesthetic?

A

ENT

183
Q

what is a beneficial property of bupivicaine?

A

longer duration of action than lidocaine

184
Q

what is a serious side effect of bupivacaine?

A

cardiotoxic

185
Q

what is the max dose of lidocaine?

A

3mg/kg or max of 200mg - 20ml (1%)

186
Q

what is the max dose of lidocaine with adrenaline?

A

7mg kg or max of 500mg - 50ml (1%)

187
Q

what is the max dose of bupivocaine 0.5%?

A

2mg/kg or max of 150mg (30ml)

188
Q

what are 5 surgeries where transfusion is unlikely?

A

simple hysterectomy
appendicectomy
thyroidectomy
elective c section
lap cholecycstecomy

do group and save no cross match needed

189
Q

what are 2 examples of surgeries where chance of transfusion is likely?

A

salpigectomy for rupture ectopic
total hip replacement

cross match 2 units

190
Q

what are 6 examples of surgeries where chance of transfusion is definite?

A

total gastrectomy
oophrectomy
oesophagectomy
elective AAA repair
cyctectomy
hepatectomy

cross match 4-6 units

191
Q

what are 2 symptoms of malignant hyperthermia?

A

hyperpyrexia
muscle rigidity

192
Q

what causes malignant hypethermia?

A

excessive release of Ca2+ from sarcoplasmic reticulum of skeletal muscle

associated with defect on chromosome 19

193
Q

how is susceptibility to malignant hyperthermia inherited?

A

autosomal dominant

194
Q

what are 3 medications that can cause malignant hyperthermia?

A

Halothane
suxamethonium
antipsychotics - neuroleptic malignant syndrome

195
Q

what is the management of malignant hyperthermia?

A

dantrolene - 2-3mg/kg then 1mg/kg up to max of 10mg’kg

prevents Ca2+ release

196
Q
A
197
Q
A

Phase 4 (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions