Ramipril

Question 1

What class of drug is ramipril?

Answer 1

ACE inhibitor

Question 2

What is the mechanism of action of ramipril?

Answer 2

A competitive inhibitor of the angiotensin converting enzyme - inhibits the vasoconstrictor angiotensin II - leads to smooth muscle relaxation and vasodilation

Question 3

What are the indications for ramipril?

Answer 3

Hypertension
Symptomatic heart failure
Secondary prevention of HF post-MI
Type 1 diabetic nephropathy

Question 4

What are the typical starting and maintenance doses of rampiril?

Answer 4

Starting - 2.5mg
Maintenance - 10mg

Question 5

How is ramipril titrated?

Answer 5

Starting dose of 2.5mg - dose is increased at interval of 2-4 weeks, up to a maximum of 10mg

Question 6

What are the common side effects of ramipril?

Answer 6

Dry cough
Hyperkalaemia
First dose hypotension

Question 7

What are the important side effects of ramipril?

Answer 7

Acute renal failure
Cholestatic jaundice
Angioedema
Hypersensitivity reactions

Question 8

What are the cautions for ramipril?

Answer 8

Renal impairment
Patients taking diuretics
Severe aortic stenosis
Avoid in pregnancy

Question 9

What are the contraindications to ramipril?

Answer 9

Concurrent use with aliskerin in patients with eGFR less than 60, or diabetes
History of angioedema associated with ACE inhibitor use
Hereditary or idiopathic angioedema