Fungal Disease

Question 1

What are some clinical findings of fungal disease?

Answer 1

• Anorexia
• Weight loss
• Fever
• Lymphadenomegaly
• Hepatosplenomegaly
• Skin lesions (commonly on the nasal planum, face, and nail beds)

Question 2

How do you treat fungal disease?

Answer 2

Oral Antifungal (-azole drug)

Question 3

This Antifungal penetrates bone well but poorly penetrates CNS and ocular tissues

Answer 3

Itraconazole

Question 4

This Antifungal has a similar efficacy as itraconazole but may require longer course of treatment and costs less

Answer 4

Fluconazole

Question 5

This Antifungal carries a serious risk of nephrotoxicity and is only given with patients that are unable to take an oral antifungal or their infection is resistant to -azole drugs

Answer 5

Amphotericin B

Question 6

Anti-inflammatory doses of this are given to dampen pulmonary inflammation associated with fungal infections

Answer 6

Corticosteroids

Question 7

This is a systemic mycotic infection caused by the Dimorphic fungus. It’s mycelial stage is found in soil and it converts to yeast form in the lungs

Answer 7

Histoplasmosis