Lecture 22

Question 1

Which of the following provides evidence for a role of genetic factors in disease risk?

Answer 1

Higher concordance rate among monozygotic twins than among dizygotic twins.
There is a high prevalence/incidence rate of identical twin pairs who have a disease compared to fraternal twins. Both twin pairs share the same environment. However, only the monozygotic twins share the same genetic information 100%. The fraternal twins share 50%?

Question 2

The Type 1 error rate used in a GWAS is typically set at 5 * 10 ^-8 because

Answer 2

Investigators want to reduce the type 1 error rate when performing multiple tests. Type 1 error is known as a (False Positive)
We commonly keep this low below 5%.