Proteinopathies Flashcards

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1
Q

List four neurodegenerative diseases the protein aggregates are found in

A

Alzheimer’s, Parkinson’s Huntington’s disease, ALS

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2
Q

List the clinical phenotype and molecular pathology for parkinson

A

Clinical phenotype: MSA, PSP, PD, and LBD
Molecular pathology: alpha-synuclein

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3
Q

List the clinical phenotype and molecular pathology for alzheimer’s disease

A

clinical phenotype: LO, AD, EO, PCA
Molecular path: alpha beta 42, p-Tau

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4
Q

What are biomarkers for DOPA?

A

Flurodopa PET, Troda SPECT

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5
Q

List the clinical phenotype and molecular pathology for FTD-ALS spectrum

A

Molecular pathology: Tau, TDP-43, FUS, UPS
Clinical phenotype: PPA (iogopenic and semantic and nonfluent), bvFTD, fvAD, ALS

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6
Q

What are biomarkers for amyloid?

A

ABeta 42 in CSF
AMyloid PET (PIB, AV45, etc)

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7
Q

What are biomarkers for Tau?

A

p-tau in CSF, tau PET (Flortaucipir, etc)

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8
Q

What are biomarkers for neurodegeneration?

A

MRI scan
T-Tau in CSF
FDG-PET

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9
Q

PH-Tau injection leads to __ __ 6 months post-injection

A

cognitive decline

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10
Q

Tau binds tightly to __

A

microtubules

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11
Q

PH-Tau disrupts __ and induces __ __

A

microtubules
membrane blebbing

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12
Q

T/F: PH-Tau toxic behavior can be transferred from cell to cell

A

True! like a prion-effect

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13
Q

PH-Tau __ neighboring cells and disrupts __

A

invades, microtubules

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14
Q

Transfer of PH-Tau between cells is __ __

A

cell specific

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15
Q

Recombinant Tau and PH-Tau enter cells that express __ __

A

muscarinic receptors

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16
Q

Recombinant tau and PH-tau enter __ neurons within __ __

A

primary
24 hours

17
Q

Treatment of PH-Tau with __ blocks the __

A

atropine, uptake

18
Q

In Alzheimer Disease P-Tau as PH-Tau is uptaken in the __ and destroys __

A

neurons; microtubules

19
Q

T/F: atropine treatment blocks AD P-tau uptake

A

true

20
Q

tcDCs reduces __ __ and upregulates HSP70 __

A

Tau accumulation
expression

21
Q

Tau pathology is __ and is pivotal in the pathogenesis of __ and other tauopathies

A

primary
AD

22
Q

Abnormal __ of tau is an early step in the process of __ degeneration

A

hyperphosphorylation
neurofibrillary

23
Q

The combination of __ at Thr212, 231, and SER199 and 262 in the same tau molecule can trigger __ in __ and __

A

phosphorylation
toxicity
vitro, in vivo

24
Q

List four new inducible mouse model recapitulates

A

oligomeric tau
truncated tau
early cognitive impairment
neuronal loss and astrocytes activation

25
Q

Tau can be __ from one __ to the next. Blocking __ receptors with __ resulted in __ of tau uptake

A

transferred, neuron
muscarinic, atropine
prevention

26
Q
A