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CCC Year 4 > PASTEST QS > Flashcards

PASTEST QS Flashcards

1
Q

What is the earliest symptom of metastatic spinal cord compression?

A

Back pain usually presents first. It is usually worse on lying flat and when coughing

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2
Q

What tumour markers are used to detect recurrence of testicular teratoma?

A

Alpha-fetoprotein + beta-HCG

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3
Q

How to convert from oral morphine to subcutaneous morphine

A

Divide by 2

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4
Q

Conversion from oral oxycodone to subcutaneous diamorphine

A

Divide by 1.5

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4
Q

How to convert from oral morphine to subcutaneous diamorphine

A

Divide by 3

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5
Q

What is Gardner’s syndrome?

A

A variant of familial adenomatous polyposis coli that causes development of adenomatous polyps in the colon and rectum.

If left untreated, 100% risk of becoming malignant and leading to colorectal cancer

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6
Q

What is Lynch syndrome?

A

Autosomal dominant condition that leads to colon or endometrial cancer at a young age. Strong family hx of family members dying of colorectal cancer at age 25-30.

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7
Q

Which chemotherapy agent is most likely to cause haemorrhagic cystitis?

A

Cyclophosphamide

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8
Q

Which chemotherapeutic agent causes periperal neuropathy

A

Vincristine

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9
Q

Which anti-emetic is most suitable for bowel obstruction in end of life care?

A

Hyoscine butylbromide maximum of 200mg/24hours

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10
Q

What are the symptoms of Lambert-Eaton Syndrome?

A

Proximal muscle weakness e.g. difficulty getting up and out of chair
Peripheral neuropathy
Impotence

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11
Q

What type of cancer is Lambert Eaton syndrome most associated with?

A

Bronchial carcinoma

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12
Q

What treatment is given for mild to moderate oral candida secondary to immunosuppression from chemotherapy?

A

Oral fluconazole for 7-14 days

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13
Q

What is given to treat Candida infection?

A

Nyastatin mouth wash

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14
Q

What is the medication/management for pulmonary metastases?

A

Systemic opioids (oral/subcutaneous/intravenous)

This has shown evidence of alleviating dyspnoea in terminally ill patients

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15
Q

How do you convert from codeine to morphine?

A

Divide by 10

16
Q

For end of life respiratory secretions, what dose of Hyoscine Bromide is used?

A

BNF recommends 400 micrograms every 4 hours of hyoscine hydrobromide by subcutaneous injection or may be more if required for respiratory secretions in palliative care.

17
Q

What cancers can HPV 16 and 18 cause?

A

Tongue and cervical

18
Q

What drug is specifically used for metastatic bone pain?

A

Intravenous ibandronate
(A bisphosphonate)

19
Q

Which chemotherapy agents are used for treatment small cell carcinoma of the lungs?

A

Cyclophosphamide, doxorubicin and Vincristine

20
Q

Which drugs are used to manage remission induction of Acute Lymphoid Leukaemia?

A

Daunorubicin plus cytarabine

21
Q

Which anti emetic is first line for gastric stasis causative nausea?

A

Metoclopramide

22
Q

Which anti-emetic is used in patients with Parkinson’s disease?

A

Domperidone as it doesn’t cross the blood-brain barrier so it is less likely to increase EPSEs

23
Q

Which anti emetic is used for raised Intracranial pressure?

A

Cyclizine (+ Dexamethasone)

24
Q

Which anti emetic is given for anxiety related N+V?

A

Lorazepam

25
Q

Treatment for drug induced and metabolic induced N+V

A

Haloperidol

26
Q

What other condition is small cell lung carcinoma associated with i.e. what does it secrete?

A

ACTH - SIADH associated

27
Q

Squamous cell lung cancer is most associated with secretion of what hormone?

A

squamous cell carcinoma is known to produce parathyroid hormone-related protein,

This causes hypercalcaemia.

28
Q

How can Hodgkin’s lymphoma positive cells be referred to?

A

Pleomorphic giant cells which have binuclear cells.

Reed-Sternberg cells

29
Q

Which type of cancer is myasthenia gravis most associated with?

A

Thyoma

30
Q

Presentation of myasthenia gravis

A

Diplopia
Ptosis
Proximal muscle weakness
Antibodies to acetylcholine receptors (85-90% of patients)

CCC Year 4 (16 decks)

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