Antineoplastic Drugs

Question 0

Antineoplastic, alkylating agents. Cross links in DNA, not platinum containing

Answer 0

Melphalan, Busulfan

Question 1

Antineoplastic. Alkylating agent. Inhibits DNA synthesis via causing cross linkages. Contains platinum.

Answer 1

Cisplatin

Question 2

Antineoplastic, alkylating agent. Forms cross linkages between DNA strands and prevents DNA synth. Can cause hemorrhagic cystosis via acrolein intermediate.

Answer 2

Cyclophosphamide

Question 3

Antineoplastic, antimetabolite. Folate antimetabolite that inhibits DNA synthesis, repair and cellular replication. Irreversibly binds to dihydrofolate reductase inhibiting the formation of reduced folates, and thymidylate synthetase, resulting in inhibition of purine and thymidylic acid synthesis

Answer 3

Methotrexate

Question 4

Antineoplastic, anthracycline. Inhibition of DNA and RNA synthesis by intercalation between DNA base pairs by inhibition of topo II and by steric obstruction. Iron chelator, free radical production which cleaves DNA and cell membranes

Answer 4

Doxorubicin

Question 5

Inactivates acrolein via adding a thiol group. Administered with cyclophosphamide to prevent side effects

Answer 5

Mesna

Question 6

Antineoplastic. Binds to TopoII and inhibits DNA replication.

Answer 6

Etoposide

Question 7

Antineoplastic and alkylating agent. Alkylates DNA at the N7 position of guanine

Answer 7

Ifosfamide

Question 8

Antimetabolic agent. Inhibits DNA synthesis and repair; inhibits ribonucleotide reductase; incorporation drug triphosphate into DNA; induction of apoptosis synthetic purine antag

Answer 8

Fludarabine

Question 9

Antimetabolic agent. Inhibits DNA chain elongation, DNA synthesis and repair; inhibits ribonucleotide reductase with reduced formation of dNTPs; incorporation of drug into DNA

Answer 9

Cytarabine

Question 10

Used in junction with methotrexate to increase tetrahydrofolate supply

Answer 10

leucovorin