17- Peripheral Arterial Disease Flashcards
stenosis of the aorta or arteries in the limbs
leading cause of PAD in patients >40 yo
what might be the cause of PAD in a young female pt.?
does everyone with PAD know it?
10-30% are symptomatic
modifiable risk factors for atherosclerosis
how is diabetes a risk factor for atherosclerosis
endothelial cell dysfunction and inflamamtion
how is HTN a risk factor for atheroscleroiss?
increased shear stress = decreased NO, increased inflammation and endothelial remodeling
how is tobacco exposure an atherosclerosis risk factor?
vasoconstriction and pro-inflammatory substances
why is obesity a risk factor for atherosclerosis?
the greatest risk factor for PAD
non-modifiable risk factors for atherosclerosis
leukocytes, C reactive prtn and monocytes correlate with…
serum bilirubin correlates with..
PAD is correlated with leukocytes, c-reactive prtn and monocytes (inflammatory disease)
serum bilirubin is associated with reduced PAD prevalence
oxygen demand of skeletal muscle during effort exceeds the blood’s oxygen supply =
*cardinal symptom PAD
flow through an artery is ______ related to perfusion pressure and _________ related to vascular resistance
Flow = pressure/resistance
which type of fibers are lost with partial axonal denervation in legs affected by PAD?
type II glycolytic fast-twitch fibers are lost
–> decreased muscle strenght and acapacity
the hallmark of all diabetic complications is…
because chronic metabolic changes lead to vasoconstriction, chronic inflammation and tendency towards thrombosis