17.2 - Spinal cord lesions Flashcards Preview

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Flashcards in 17.2 - Spinal cord lesions Deck (12)
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1
Q

syringomyelia results in sensory loss of pain and temperature with sparing of fine touch and position in the upper extremities due to involvement of the _____________ of the _____________

A
  • anterior white commissure

- spintothalamic tract

2
Q

how does syringomyelia present?

A
  • cape like distribution of sensory loss
  • muscle atrophy and weakness with decreased muscle tone and impaired reflexes
  • horner syndrome
3
Q

why does horner syndrome result from syringomyelia?

A

disruption of the lateral horn of the hypothalamospinal tract

4
Q

werdnig hoffman disease is an inherited degeneration of the ______________ and the inheritance is ________

A
  • anterior motor horn

- AR

5
Q

ALS is a degenerative disorder of upper and lower motor neurons of the _____________ tract

A

corticospinal

6
Q

what is an early sign of ALS?

A

atrophy and weakness of hands

7
Q

what mutation occurs in some familial cases of ALS?

A

Cu/Zn SOD mutation

8
Q

friedrich ataxia is a degenerative disorder of the ________ and _________

A

cerebellum and spinal cord

9
Q

what is the inheritance of friedrich ataxia?

A

AR

10
Q

friedrich ataxia is due to n unstable trinucleotide repeat of ______ in the _________ gene

A
  • GAA

- frataxin

11
Q

what is the normal role of frataxin? what happens when it is lost?

A
  • mitochondrial iron regulation

- free radical damage

12
Q

friedrich ataxia is associated with _______________ cardiomyopathy

A

hypertrophic

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