Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Basic Immunology > Lecture 2 (Week 1B) - Lymphocyte Formation > Flashcards

Lecture 2 (Week 1B) - Lymphocyte Formation Flashcards

1
Q

The cells of the immune system work as

A

an INTEGRATED DEFENSE system to eliminate or control an infectious agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The immune system provides

A

LONG-LASTING PROTECTIVE IMMUNITY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pathogens target various

A

compartments of the body

which require different host defense mechanisms for eradication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Extracellular host defense mechanisms

A

blood, lymph, interstitial spaces
• antibodies
• complement
• phagocytosis

epithelial surfaces
• antibodies (IgA)
• antimicrobial peptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antibodies abbreviation

A

IgA

Ab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Intracellular host defense mechanisms

A

cytoplasmic
• cytoxic T cells
• NK cells

vesicular
• T cell-dependent macrophage activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Immunogen

A

anything which elicits an immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Antigen

A

anything recognized by a
• B cell receptor (antibody or
• T cell receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

An antigen is a part

A 
of something which our bodes may encounter
• bacteria
• virus
• fungi
• parasite
• food protein
• pollen 
etc
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

All immunogens are

A

all immunogens are antigens
BUT
all antigens are not immunogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Hapten

A

injected into an animal = no immune response

eg DNP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

A hapten is

A

a hapten is a antigen, but it is NOT an immunogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Protein carrier

A

injected into animal = anti-BSA Ab

eg BSA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hapten-carrier

A

congugate injected into animal =
anti-BSA Ab
anti-DNP Ab
eg DNP-BSA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Epitopes

A

immunologicallly active parts of an antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Antibodies (Abs) can bind to

A

epitopes on antigens

17
Q

The lymphoid system

A
  • primary lymphoid tissue

* secondary lymphoid tissue

18
Q

Primary lymphoid tissue

A

where lymphocytes are made
• Thymus - T cells
• Bone marrow - B cells and NK cells

19
Q

B of B cell

A

is for Bursa (the primary lymphoid tissue for B cells in birds)
• NOT FOR BONE-MARROW

20
Q

Bursa

A

the primary lymphoid tissue for B cells in birds

21
Q

Secondary lymphoid tissue

A 
where immune responses occur
• lymph nodes
• spleen
• tonsils
• Peyer's patches (gut)
• appendix
22
Q

Primary lymphoid tissue size

A

size is antigen-independent

23
Q

Secondary lymphoid tissue size

A

size is antigen-dependent

eg secondary lymphoid tissue in the gut

24
Q

Lymphatic vessels

A

allow fluid to drain from the tissues into lymph nodes
• the lymphatic system is designed to get antigens into lymph nodes, where the antigens can stimlate T cells and B cells

  • “draining lymph node”
  • afferent lymphatic vessel
25
Q

The lymphatic system is designed to

A

get antigens into lymph nodes, where the antigens can stimulate T cells and B cells
• “draining lymph node”
• afferent lymphatic vessel

26
Q

T and B cells reside in

A

different parts of the lymph nodes
• T cells = paracortex
• b cells
• germinal center

27
Q

High Endothelial Venule (HEV)

A

HEVs are specialized post-capillary venous swellings that allow circulating lymphocytes to leave the blood and enter the lymph nodes

28
Q

The spleen is the lymphoid tissue which

A

samples antigens in the blood

• splenectomised individuals are more susceptible to blood infections = septicaemia

29
Q

Splenectomised individuals are more susceptible to blood infections = septicaemia

A

blood infections = septicaemia

30
Q

Splenic structure

A

white pulp
• primary follicle
• marginal zone
• periarteriolar lymphoid sheath (PALS)

artery and vein

31
Q

In mammals, B cells develop from

A 
stem cells in the bone marrow
• stem cells -->
• Pro-B cells -->
• Pre-B cells -->
• immature B cells 
(--> mature naive B cells)
32
Q

B cells become

A

plasma cells which produce huge amounts of diverse antibodies

33
Q

Plasma cells produce

A

huge amounts of diverse antibodies

34
Q

T cells recognize antigens using their

A

T Cell Receptor (TCR)
• αβ TCR
- TCRβ
-TCRα

• γδ TCR

  • TCRγ
  • TCRδ
35
Q

T cells are generated in

A

the thymus

a primary lymphoid tissue

36
Q

Thymus structure

A

cortex (outside)

medulla (inner part)

37
Q

The thymic gland … with …

A

involutes with age

38
Q

All T cells develop from

A

a common bone marrow-derived progenitor in the thymus

39
Q

After eg a serious cut, dendritic cells to go

A

the draining lymph nodes

Basic Immunology (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions