Non-Hodgkin's Lymphoma

Question 1

Follicular Lymphoma

Answer 1

Neoplastic B-cells make follicle-like nodules. Derives from germinal center.

t(14;18) –> overexpression of BCL-2 –> inhibits apoptosis.

Generalized LAD: lymph nodes contain LOTS of follicles.

Question 2

Mantle Cell Lymphoma

Answer 2

B=cells that expand in the mantle zone.

Associated with chronic inflammatory states

t(11;14) –> translocation of cyclin D1 –> overexpression –> increased G1/S phase transition.

Question 3

Marginal Zone Lymphoma

Answer 3

Associated with H. pylori and chronic inflammatory states.

Often presents as low-grade malignant lymphoma of the stomach.

Question 4

Burkitt Lymphoma

Answer 4

Associated with Epistein Barr Virus.

African: jaw Sporadic: abdomen

t(8;14) –> overexpression of c-myc –> increased cell growth.

High mitotic/death rate –> “starry sky” appearance (dead cell are eaten away by macrophages).

Question 5

Diffuse Large B-cell Lymphoma

Answer 5

Enlarging lymph nodes, GI tract mass or brain mass.

Can arise sporatically or from follicular lymphoma.