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D&D Drugs > Drug by Adverse Reaction > Flashcards

Drug by Adverse Reaction Flashcards

1
Q

Penicillin G

A

rash, anaphylaxis, convulsions

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2
Q

Penicillin V

A

rash, anaphylaxis, convulsions

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3
Q

Penicillinase-resistant

A

rash, anaphylaxis, convulsions

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4
Q

Amoxicillin

A

diarrhea, CDAD possible

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5
Q

Cephalexin

A

allergy

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6
Q

Cefaclor, Cefuroxime

A

DDI: enhances Warfarin, anticoags possible

CDAD possible

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7
Q

Cefdinir, Ceftriaxone

A

CDAD possible

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8
Q

Vancomycin

A

chills/fever/rash

ototoxicity, renal toxicity (monitor Cp)

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9
Q

Carbapenems

A

nausea/vomiting, diarrhea, possible seizures

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10
Q

Azythromycin

A 
GI disturbances (n/v, diarrhea)
DDI's due to P450 metabolism
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11
Q

Doxycycline

A

abn tooth/bone development, fungal suprainfection
DDI with metal cations (antacids, dairy, iron)
Avoid in pregnancy

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12
Q

Minocycline

A

abn tooth/bone development, fungal suprainfection
DDI with metal cations (antacids, dairy, iron)
Avoid in pregnancy

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13
Q

Clindamycin

A

severe diarrhea

pseudomembranous colitis

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14
Q

Aminoglycoside

A

vestibular/auditory toxicity

nephrotoxicity (monitor Cp)

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15
Q

Chloramphenicol

A

bone marrow toxicity

gray baby syndrome, GI upset

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16
Q

Oxazolidinones

A

well tolerated

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17
Q

Streptogamins

A 
infusion-related pain, phlebitis
inhibits CYP3A4 (DDI's)
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18
Q

Ciprofloxacin

A

well-tolerated, CDAD possible
DDI with theophylline/antacids
Do not give to children

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19
Q

Levofloxacin

A

well-tolerated, CDAD possible
DDI with theophylline/antacids
Do not give to children

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20
Q

Nitrofurantoin

A

GI

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21
Q

Metronidazole

A

nausea, headache, GI

Antabuse-like rxn

22
Q

Sulfamethoxazole/Trimethoprim

A

hypersensitivity skin rxns

decreased H2O solubility of metabolites

23
Q

Isoniazid

A

hepatotoxicity, neuritis, allergic rxns

24
Q

Rifampin

A

liver function impairment
colors excretions orange-red
induces CYP1A2, 2C9-19, 3A4

25
Q

Ethambutol

A

optic neuritis, rash

avoid in children

26
Q

Pyrazinamide

A

hepatotoxicity, hyperuricemia

27
Q

Streptomycin

A

8th nerve toxicity

28
Q

Amphotericin

A

fever/chills with infusion

nephrotoxicity

29
Q

Nystatin

A

well tolerated

30
Q

Caspfungin

A

rash, pruritus, n/v with infusion

31
Q

Fluconazole

A

well tolerated

32
Q

Terbinafine

A

headache, diarrhea, rash

inhibits CYP450

33
Q

Flucytosine

A

n/v, rashes, bone marrow depletion

34
Q

Griseofulvin

A

hypersensitivity rxns, GI distress, confusion

35
Q

Acyclovir

A

minor toxicities (headache, n/v)

36
Q

Valacyclovir

A

minor toxicities (headache, n/v)

37
Q

Entacavir

A

well tolerated

38
Q

Tenofovir

A

well tolerated usually

lactic acidosis, HSM in HIV pt’s

39
Q

Interferon-α

A

flu-like symptoms, bone marrow depression, neurobehavioral changes

40
Q

Ribavirin

A

low aerosol toxicity

systemic toxicity: anemia, bone marrow depression

41
Q

Telaprevir, Boceprevir

A

rash common (possibly severe)

42
Q

Sufosbuvir

A

well tolerated overall

fatigue, nausea, insomnia

43
Q

Emtricitabine

A

best tolerated HIV, hypersensitivity

44
Q

Tenofovir

A

well tolerated HIV, hypersensitivity

45
Q

Efavirenz

A

CNS effects

46
Q

Atazanavir

A

rash, bilirubinemia/jaundice

47
Q

Darunavir

A

severe rash/ DJ syndrome

48
Q

Ritonavir

A

Gi, hepatotoxicity

49
Q

Raltegravir

A

relatively well tolerated
GI upset, sweating
DDI increase with glucuronidation inducer

50
Q

Enfuvirtide

A

injection site inflammation

51
Q

Maraviroc

A

mild GI, HA, URI, insomnia, rash

DDI with ART that inhib/induce CYP3A4

52
Q

Antipseudomonal

A

diarrhea, CDAD possible

D&D Drugs (7 decks)

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