pharm exam 1 random

Question 0

under what situation is a pt. at increased risk of orthostatic HTN?

Answer 0

if they’re on an alpha blocker

adrenoceptor ANTAGONIST

Question 1

different receptor types effect on adenylyl cyclase - and what it leads to

Answer 1

• alpha 2 agonists INHIBIT

- beta agonists ACTIVATE –> thus inc. levels of cAMP, –> inc. heart contraction

Question 2

implications for dentistry for a pt. on alpha blocker (adrenoceptor antagonist)

Answer 2

• inc. risk of orthostatic HTN
• more absorption of LA (vasoconstriction by endogenous SNS hormones is blocked)
• cardiotox. of beta agonist
• can speed reversal of LA effect

Question 3

for LA, if pt. is taking an alpha-1 selective blocker, which vasoconstrictor would you use?

Answer 3

levonordefrin (b/c it vasoconstricts through the alpha-2 receptor)

Question 4

which alpha antagonists cause LESS reflex tachycardia?

Answer 4

the alpha-1 selective ones (b/c they don’t block alpha-2 receptors)

Question 5

what can prazosin be used for?

Answer 5

treat high BP

alpha blocker

Question 6

tamsulosin

Answer 6

alpha blocker

treat incontinence

Question 7

alfuzosin

Answer 7

alpha-blocker

treat high BP

Question 8

which type of alpha receptor blocker stimulates NE release?

Answer 8

alpha-2

it removes the “brake” exerted by NE on its own release

Question 9

what drugs can tx glaucoma?

Answer 9

beta adrenergic blockers

Question 10

dental implications:

what can a centrally acting alpha agonist cause?

Answer 10

xerostomia

Question 11

name 2 centrally acting alpha-2 agonists

Answer 11

clonidine

alpha-methyl dopa

Question 12

which organs receive innervation from both symp and parasymp?

Answer 12

heart
lungs
salivary glands
abdominal and pelvic viscera (gut, bladder, etc)

Question 13

where is pseudocholinesterase found?

Answer 13

primarily in plasma and the liver

as opposed to acetylcholinesterase, found in neuron synapses