19.3

Question 1

genome annotation

Answer 1

-a DNA sequence is of little importance without information about the genes
-genome annotation assigns informaiton about DNA sequences
*Genbank
*BLAST

Question 2

Encyclopedia of DNA elements (ENCODE)

Answer 2

-importance of non-coding DNA has remained unclear
-ENCODE project created to identify functional elements in the human genome
*claims 80% functional
*reproducible “biological activity”- functional
disagreements:
not sufficient
-sites of enzymatic are not not necessarily functional